If you're planning on getting infused with young blood to fight memory loss and aging, the US Food and Drug Administration would like you to reconsider.FDA Commissioner Scott Gottlieb and Peter Marks, director of the Center for Biologics Evaluation and Research, warned in a Tuesday statement against getting infused with blood plasma from young donors.Claims that these infusions can help treat conditions such as dementia, Parkinson's disease, Alzheimer's disease, heart disease and post-traumatic stress disorder haven't been clinically proven, the FDA said."We have significant public health concerns about the promotion and use of plasma for these purposes," Gottlieb and Marks said."There is no proven clinical benefit of infusion of plasma from young donors to cure, mitigate, treat, or prevent these conditions, and there are risks associated with the use of any plasma product."The FDA said it's alerting consumers and health care providers that treatments using young blood haven't gone through the appropriate testing to confirm their therapeutic benefit and safety.
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Alzheimer Disease Treatment in India.Alzheimer's disease (AD), also referred to simply as Alzheimer's, is a chronic neurodegenerative disease that usually starts slowly and worsens over time.It is the cause of 60–70% of cases of dementia.The most common early symptom is difficulty in remembering recent events (short-term memory loss).As a person's condition declines, they often withdraw from family and society.Gradually, bodily functions are lost, ultimately leading to death.
PHOENIX, Ariz. -- Feb. 13, 2019 -- Dr. Winnie Liang, Director of Scientific Operations at the Translational Genomics Research Institute (TGen), an affiliate of City of Hope, has been named by the Phoenix Business Journal as one of Arizona's 2019 Outstanding Women in Business."I am incredibly flattered by this honor and to be recognized amongst other amazing women in Phoenix, but this is truly a testament to all the tremendous work being pursued here at TGen to benefit patients with health challenges, ranging anywhere from infectious diseases to diabetes to different types of cancer, and as well as my focus in Alzheimer's disease research," said Dr. Liang, who was selected as one of 25 Outstanding Women in Business from more than 280 nominations.Dr. Liang received a Bachelor of Science in Biological Sciences from Carnegie Mellon University, and her Ph.D. in Molecular and Cellular Biology from Arizona State University.As an Associate Professor at TGen, Dr. Liang has continued her graduate and post-doctoral work in Alzheimer's disease research.She is an active member of the Arizona Alzheimer's Consortium, and currently co-leads a multi-institutional study with ASU, the Banner Alzheimer's Institute, Banner Sun Health Research Institute, and Mt.In 2010, Dr. Liang led the creation of TGen's Collaborative Sequencing Center, which acts as TGen's primary next-generation sequencing resource, using precision medicine to unlock the mysteries of the human genome and provide patients and their attending physicians with new insights into their diseases and conditions.
The researchers, led by the University of Cambridge, used their algorithm to identify four new molecules that activate a protein which is thought to be relevant for symptoms of Alzheimer's disease and schizophrenia.The results are reported in the journal PNAS.A key problem in drug discovery is predicting whether a molecule will activate a particular physiological process.It's possible to build a statistical model by searching for chemical patterns shared among molecules known to activate that process, but the data to build these models is limited because experiments are costly and it is unclear which chemical patterns are statistically significant."Machine learning has made significant progress in areas such as computer vision where data is abundant," said Dr Alpha Lee from Cambridge's Cavendish Laboratory, and the study's lead author.The algorithm developed by Lee and his colleagues, in collaboration with biopharmaceutical company Pfizer, uses mathematics to separate pharmacologically relevant chemical patterns from irrelevant ones.
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This report studies the global market size of AlzheimersDisease Diagnostic in key regions likeNorth America, Europe, Asia Pacific, Central & South America and MiddleEast & Africa, focuses on the consumption of Alzheimers Disease Diagnostic in these regions.This report also studies theglobal market status, competition landscape, market share, growth rate, futuretrends, market drivers, opportunities and challenges, sales channels,distributors and Porter’s Five Forces Analysis.Market size split by RegionRest of Central & South AmericaDo Inquiry Before Accessing Global Alzheimers DiseaseDiagnostic Market Report at https://www.orbisresearch.com/contacts/enquiry-before-buying/2328002 .Focuses on the key global Alzheimers Disease Diagnostic manufacturers, todefine, describe and analyze the sales volume, value, market share, marketcompetition landscape, SWOT analysis and development plans in next few years.
This report studies the global market size of AlzheimersDisease Diagnostic in key regions likeNorth America, Europe, Asia Pacific, Central & South America and MiddleEast & Africa, focuses on the consumption of Alzheimers Disease Diagnostic in these regions.This report also studies theglobal market status, competition landscape, market share, growth rate, futuretrends, market drivers, opportunities and challenges, sales channels,distributors and Porter’s Five Forces Analysis.Market size split by RegionRest of Central & South AmericaDo Inquiry Before Accessing Global Alzheimers DiseaseDiagnostic Market Report at https://www.orbisresearch.com/contacts/enquiry-before-buying/2328002 .Focuses on the key global Alzheimers Disease Diagnostic manufacturers, todefine, describe and analyze the sales volume, value, market share, marketcompetition landscape, SWOT analysis and development plans in next few years.
The image of a lab rat is an iconic symbol of scientific research, and for good reason: These rodents are remarkably good stand-ins for human subjects because of how closely their physiology and genetic make-up resemble ours.Because of this, mice and rats are used to study everything from cancer to diabetes to Alzheimer’s disease.However, despite their tried-and-true use as animal models, there’s something about these rodents that puzzles scientists: What is all the squeaking about?Up until now, researchers have relied heavily on ambiguous physical cues—such as rats pressing a lever to receive a dose of an addictive substance—or time-consuming manual analysis of rodent chatter to try to understand what drives their behaviour during trials.Both of these methods are vulnerable to human error and misinterpretation.Similar to how a self-driving car might take in and evaluate visual data from the road in front of it, DeepSqueak transforms audio recordings of rodent calls into sonogram images and then uses machine vision to analyse them.
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If cells cannot clear these away, they become toxic and prevent cells working properly.This discovery, led by scientists at the Centre for Genomic Regulation (CRG) in Barcelona, reveals that RNAs act as a 'scaffold' to hold several proteins that stick to RNAs together, and that certain RNA molecules with distinct properties attract more proteins and encourage proteins to aggregate.Many neurodegenerative diseases are linked to protein aggregation, including amyotrophic lateral sclerosis and Alzheimer's disease.We know that proteins can form toxic aggregates, but until now, the contribution of nucleic acid molecules such as RNA has been up for debate.CRG researcher and ICREA Research Professor Gian Gaetano Tartaglia and CRG Alumni Teresa Botta-Orfila, and currently at Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), wanted to understand how RNA can promote aggregation.In their research, published in the journal Cell Reports, they discovered that specific RNAs do indeed interact with many proteins within cells, and that these RNAs have distinct properties - they are structured, have a long area of untranslated genetic code called a UTR region, and often contain several repeats of genetic code (called CGG expansions) within them.
There has been some noise raised around facial recognition lately, especially those in use by corporations and authorities.But while misuse of such technology is valid cause for concern, there are some younger, more optimistic minds that are thinking outside the box to use facial recognition for good.One such mind is 14-year-old Emma Yang whose Timeless app is making waves because of it aims to use the same technology applied to identify criminals and suspects for identifying family and friends for those stricken by Alzheimer’s disease.Emma’s motivation for the app is a personal one.Two years ago, she started noticing her grandmother started to forget things, from birthdays to even what she just recently ate.For a young girl, that would have been an emotionally depressing experience.
Thursday, January 31, 2019 - Insilico Medicine, a Rockville-based company developing the end-to-end drug discovery pipeline utilizing the next generation artificial intelligence, will present its latest results in modern and next-generation AI for Drug Discovery on a live episode of the influential CXOTalk Show on February 8, 2019 at 1:00 PM Eastern time.With AI comes the potential to improve drug approval rates, reduce development costs, get medications to patients faster and help patients comply with their treatments.At Insilico, AI has been used as a powerful tool to identify targets for drug development, and with the ability to simulate and accelerate research processes, AI helps more drugs to be discovered and come to market quickly.The topic of AI for Drug Discovery is rapidly gaining popularity, and we are happy to be at the leading edge of research and one of the innovation drivers in the area", says Alex Zhavoronkov, Ph.D., Founder, and CEO of Insilico Medicine, Inc.Industry analyst and host of CXOTalk, Michael Krigsman, said, "Dr. Zhavoronkov and Insilico are prominent voices in using AI for drug discovery.The event will go live on the 8th of February 2019, at 1 PM ET.
It might be possible to prevent cognitive decline by aggressively treating a person’s high blood pressure, the study found.It recruited nearly 10,000 volunteers over the age of 50 with high blood pressure and at least one other risk factor for cardiovascular disease, like smoking.The latter threshold was, at that point, considered standard care.Cardiovascular disease was the main health outcome examined by the SPRINT study, which ended early in 2015 after it became apparent that aiming for 120 was better at preventing things like heart attacks and stroke than standard care.But a subset of around 8,500 volunteers were also studied for their potential risk of dementia and mild cognitive impairment (MCI), an earlier stage of memory loss and brain drain that often progresses to dementia.It found that aggressively treated, relatively healthy people were significantly less likely to develop MCI than people given standard care.
In a new study, USC researchers used machine learning to identify potential blood-based markers of Alzheimer's disease that could help with earlier diagnosis and lead to non-invasive ways of tracking the progress of the disease in patients.The method was developed by USC computer science research assistant professor Greg Ver Steeg, a senior research lead at the USC Information Sciences Institute (ISI)."This type of analysis is a novel way of discovering patterns of data to identify key diagnostic markers of disease," said team member Paul Thompson, the associate director of the USC Mark and Mary Stevens Neuroimaging and Informatics Institute and professor in the Keck School of Medicine at USC.The study, "Uncovering Biologically Coherent Peripheral Signatures of Health and Risk for Alzheimer's Disease in the Aging Brain," appeared in Frontiers in Aging Neuroscience, The study authors are from the USC Mark and Mary Stevens Neuroimaging and Informatics Institute and the USC Information Sciences Institute.While most Alzheimer's research to date has focused on known hypotheses, such as the build up of amyloid plaque and tau protein in the brain, both measures have proved tricky to measure in the bloodstream.As a result, neuroscientists at USC wondered if there could be other "hidden" indicators of Alzheimer's--factors that could be detected with a routine blood test.
Researchers have found further evidence of a relationship between a munbakterie and alzheimer's disease.This could open up new treatments for dementia.Alzheimer's disease is the most common form of dementia and is estimated to be the fifth most common cause of death globally.the Disease involves nerve cells atrophy in one or several areas of the brain.There are drugs that can mitigate the disease, but none that can make the affected by alzheimer's disease healthy.There have previously been studies that have pointed towards a link between a bacteria that can cause inflammation of the gums and alzheimer's disease.
This week Alzheimer’s Disease was found to be scientifically associated with the simple act of brushing one’s own teeth.A study published this week puts PG in position to be a major factor in breaking down the brain on the pathway to Alzheimer’s Disease.In studies performed thus far, results seem to be pointing in a major way toward PG having something major to do with AD – extremely major.They discovered said protein and DNA in all of their AD patient samples, and in none of their control samples.Obviously they’ll need to run this same test again and again until they’ve got definitive results as a set of 10 brains (their living tissue test set) isn’t enough to make a conclusion just yet – but the results so far look pretty solid.Tests are marked by “gingipain load” here.
MIT researchers have developed a way to dramatically enhance the sensitivity of nuclear magnetic resonance spectroscopy (NMR), a technique used to study the structure and composition of many kinds of molecules, including proteins linked to Alzheimer's and other diseases.Using this new method, scientists should be able to analyze in mere minutes structures that would previously have taken years to decipher, says Robert Griffin, the Arthur Amos Noyes Professor of Chemistry."This technique should open extensive new areas of chemical, biological, materials, and medical science which are presently inaccessible," says Griffin, the senior author of the study.MIT postdoc Kong Ooi Tan is the lead author of the paper, which appears in Sciences Advances on Jan. 18.Traditional NMR uses the magnetic properties of atomic nuclei to reveal the structures of the molecules containing those nuclei.By using a strong magnetic field that interacts with the nuclear spins of hydrogen and other isotopically labelled atoms such as carbon or nitrogen, NMR measures a trait known as chemical shift for these nuclei.
Alzheimer's-affected brains are riddled with so-called amyloid plaques: protein aggregates consisting mainly of amyloid-β.However, this amyloid-β is a fragment produced from a precursor protein whose normal function has remained enigmatic for decades.A team of scientists at VIB and KU Leuven led by professors Joris de Wit and Bart De Strooper has now uncovered that this amyloid precursor protein modulates neuronal signal transmission through binding to a specific receptor.Modulating this receptor could potentially help treat Alzheimer's or other brain diseases.The results are published in Science.More than 30 years have passed since the amyloid precursor protein was first identified.
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PHILADELPHIA--Integral Molecular, the industry leader in membrane protein technologies, was awarded a Small Business Innovation Research (SBIR) grant from the NIH to initiate a target discovery program for Alzheimer's disease.Under the grant, Integral Molecular will use its highly successful Membrane Proteome Array (MPA) platform to discover novel neuroimmune targets for treating Alzheimer's and other neurodegenerative diseases.Neurodegenerative diseases are a leading cause of death and disability for 6.5 million older Americans.A major roadblock in the development of new treatments has been the lack of druggable targets.Recent research suggests that dysregulation of the immune system can cause or exacerbate many neurodegenerative diseases.The identification of new proteins that can regulate the neuroimmune system could enable the discovery of an entirely new generation of therapeutics with the potential to treat, delay, or even prevent Alzheimer's disease.
Sometimes data behaves so nicely, lining up just the way you want it to.In 2013, irisin was found to stimulate genes in the hippocampus, a region of the brain essential for making and storing memories.This new study makes a pretty compelling case that exercise, working through irisin, can protect memories from the neurodegeneration that wreaks such havoc on the minds and lives of Alzheimer’s patients.The researchers first showed that irisin levels are lower in the brains of people and mice with AD than in age-matched healthy controls, a correlation that indicated a closer look was called for.Experiments with cultured rat brain cells, human brain slices, and live mice showed that these amyloid β oligomers are also associated with this decrease of irisin levels in the brain.Next, the researchers showed that irisin is both necessary and sufficient for protecting memories from degradation.
LA JOLLA--(January 8, 2019) Salk scientist Saket Navlakha has received a CAREER award from the National Science Foundation (NSF) totaling more than $1 million over the next five years.The CAREER award supports faculty who exemplify the role of teacher/scholars through outstanding research, excellent education and the integration of education and research within the context of the mission of their organizations."Saket's work is as innovative as it is interdisciplinary, with an approach that spans the fields of plant biology, computer science and neuroscience to reveal fascinating patterns in nature, including the brain," says Salk President Rusty Gage."We are grateful that his research is being recognized and supported by the NSF, as it will help advance our understanding of how mathematics is intrinsically linked with the natural world, with relevance to topics as diverse as finding the causes of Alzheimer's disease or enhancing crop yields."An assistant professor in the Integrative Biology Laboratory and a Pioneer Fund Developmental Chair, Navlakha received the CAREER award to fund his proposed study, "Algorithms in nature: uncovering principles of plant structure, growth, and adaptation."The results of his study will help reveal the basic patterns that evolution has used to design these systems and will offer an improved understanding of how these natural networks process information and function in both health and disease.
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Intracranial hemorrhages — brain bleeds — are the second-most common subtype of stroke, according to the National Center for Biotechnology Information.They interrupt blood flow around or inside of the brain, depriving it of oxygen, which is why timely treatment is critical.After three or four minutes, brain cells begin to die.In a paper (“An explainable deep-learning algorithm for the detection of acute intracranial hemorrhages from small datasets”) published in the journal Nature Biomedical Engineering last month, researchers at Massachusetts General Hospital in Boston describe a deep learning algorithm that can detect acute intracerebral hemorrhages, or ICHs, with a high degree of accuracy.Their work comes about a month after researchers at the University of California, Berkeley demonstrated an AI system that can predict Alzheimer’s disease from brain scans up to six years in advance.“It is somewhat paradoxical to use the words ‘small data’ or ‘explainable’ to describe a study that used deep learning,” Hyunkwang Lee, a graduate student at the Harvard School of Engineering and Applied Sciences and one of the two lead authors of the study, told MedicalXpress.
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