BETHESDA, MD - MyGene2, a new open data resource, helps patients with rare genetic conditions, clinicians, and researchers share information, connect with one another, and enable faster gene discovery, according to results presented at the American Society of Human Genetics (ASHG) 2017 Annual Meeting in Orlando, Fla."With MyGene2, we hope to help patients and their families engage with researchers and clinicians and vice versa, as well as speed up awareness of genes associated with rare Mendelian diseases," said Jessica Chong, PhD, Analysis Group Lead at the federally-funded University of Washington Center for Mendelian Genomics (UW-CMG), who presented the work.Dr. Chong and Michael Bamshad, MD, Chief of the UW Division of Genetic Medicine, were working in rare disease gene discovery when they observed that a lack of open data sharing was slowing down scientific progress."We found that good research findings were just not getting out there," she said."Researchers may know of a gene's discovery years before it gets published, during which time patients and their families are undiagnosed and unaware."At the same time, they noted that rare disease patients and families who were using existing social networks to make connections were running up against the limitations of those platforms, such as balancing worldwide reach with patient privacy and achieving consistency in terminology.
Nanyang Technological University (NTU Singapore), one of the world's leading research-intensive institutions, and Swedish defence and security technology leader Saab, will set up a joint research centre as part of a collaboration to develop research projects and programmes in high-end digital technology.A key focus of the Saab-NTU Joint Research Centre is air traffic management, with research into areas such as artificial intelligence, cyber security, machine learning, computer vision, anomaly detection and unmanned aircraft system camera insertion.This will be followed by an annual investment for five or more years which will be matched by NTU.To initiate the partnership, NTU and Saab signed a Memorandum of Understanding (MOU) today (18 October) at the Royal Swedish Academy of Engineering Sciences, before the start of the two-day Wallenberg Autonomous Systems and Software Programme (WASP)-NTU Workshop in Stockholm.It was witnessed by NTU President Prof Bertil Andersson, Mr Marcus Wallenberg, Chairman of Saab, and Prof Subra Suresh, who will succeed Prof Andersson as NTU's fourth president on 1 January next year.NTU is proud to be Saab's partner of choice in Asia as together we forge a long-term partnership in research excellence.
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An international group of researchers led by Professor Wim Versées (VIB-VUB) has unraveled the workings of an essential mechanism in 'Parkinson's protein' LRRK2.Approximately 4 million people worldwide currently suffer from Parkinson's disease, and this number is only expected to increase.The most frequent genetic causes of the illness are mutations in the gene responsible for controlling the production of protein LRRK2, which includes two enzymes: a kinase and a GTPase.Because this kinase is at the root of neuronal problems, kinase inhibitors have already been clinically tested.However, these inhibitors eventually cause lung and kidney problems, making it imperative for scientists to seek alternative solutions.Parkinson's protein comes in a single or doubled state
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Plasma technology could hold the key to creating a sustainable oxygen supply on Mars, a new study has found.It suggests that Mars, with its 96 per cent carbon dioxide atmosphere, has nearly ideal conditions for creating oxygen from CO2 through a process known as decomposition.Published today in the journal Plasma Sources Science and Technology, the research by the universities of Lisbon and Porto, and École Polytechnique in Paris, shows that the pressure and temperature ranges in the Martian atmosphere mean non-thermal (or non-equilibrium) plasma can be used to produce oxygen efficiently.Lead author Dr Vasco Guerra, from the University of Lisbon, said: "Sending a manned mission to Mars is one of the next major steps in our exploration of space.Creating a breathable environment, however, is a substantial challenge."Plasma reforming of CO2 on Earth is a growing field of research, prompted by the problems of climate change and production of solar fuels.
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Failure prediction in Industry 4.0 may be conducted thanks to the application of Big Data which facilitates efficient management and smart analysis of large data volumes in industry to maximise productivity and competitiveness on a global scale.This technology, industrialised and patented by NEM Solutions with TECNALIA cooperation during the research and development phase, is currently being applied worldwide in the wind power and railway sectors.At the award ceremony Alberto Diez Oliván, TECNALIA researcher, expressed "we are proud to see this technology where TECNALIA has collaborated from the start, offering great results to companies in the Railway and Wind Power Sectors, through NEM Solutions products and services".On the other hand, Alberto Conde Mellado, founder and CEO of NEM Solutions, stressed "TECNALIA has been, and we hope it will continue to be, a strategic partner for us.Ten years ago, DATA was not BIG, and we launched a joint research project to turn an idea into a sustainable and scalable business line.Ten years later we are still gaining clients every month and we are recognised on the market".
Natural disasters such as Hurricane Irma are putting the nation at risk of losing parts of our American heritage.The monster storm hit St. Augustine with flooding and surge, creating grave concerns for the national monuments Castillo de San Marcos and Fort Matanzas.Made from coquina, a fragile sedimentary rock comprised of mostly shell, these masonry forts face ongoing threats from erosion and storm damage.Dr. Lori Collins and Dr. Travis Doering and their team of researchers from the Digital Heritage and Humanities Collections with the USF Libraries are working with the National Park Service to preserve the sites using 3D imaging and photogrammetry techniques that will allow for more robust management, interpretation and research into construction and conservation aspects for these sites into the future.This critical project will also assist in documenting the forts' histories and use by the British, Spanish, Native Americans, Colonial African Americans and other cultural influences.The pair will also lead a team from USF that will work alongside the National Park Service Southeast Archeological Center, to document sites in the Florida Everglades, near Irma's landfall.
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We've all heard Darwin's theory described as favoring the fittest, but new research from Michigan State University shows that, at least in small populations, it's ok to not be the best.In a paper published in Nature Communications, Christoph Adami, professor of microbiology and molecular genetics, and graduate student Thomas LaBar have provided a look at how certain species survive by evolving a greater ability to weed out harmful mutations - a new concept called "drift robustness".Drift robustness occurs when small populations normally susceptible to harmful mutations evolve to protect themselves from going extinct.The organisms rearrange their genomes so mutations either have no effect or they kill an individual organism, providing the rest of the population with a chance to stay alive."We found that organisms that always live in small groups adapt to such environments and survive, but organisms in originally large populations that become greatly reduced in size are the ones at risk, continually suffering mutation after mutation - in essence they suffered death from a thousand cuts," Adami said."Traditional thinking was that organisms from both large and small populations would have suffered equally and both gone extinct."
Professor Martijn Kemerink of Linköping University has worked with colleagues in Spain and the Netherlands to develop the first material with conductivity properties that can be switched on and off using ferroelectric polarisation.The phenomenon can be used for small and flexible digital memories of the future, and for completely new types of solar cells.In an article published in the prestigious scientific journal Science Advances, the research group shows the phenomenon in action in three specially built molecules, and proposes a model for how it works."I originally had the idea many years ago, and then I just happened to meet Professor David González-Rodríguez, from the Universidad Autónoma de Madrid, who had constructed a molecule of exactly the type we were looking for," says Martijn Kemerink.The organic molecules that the researchers have built conduct electricity and contain dipoles.A dipole has one end with a positive charge and one with a negative charge, and changes its orientation (switches) depending on the voltage applied to it.
Researchers from Concordia have made a breakthrough that could help your electronic devices get even smarter.Champagne is pleased with the reception the research has garnered."We were thrilled when our paper was accepted by Nature Communications because of the respect the journal has in the field," he says.Champagne, the study's principle investigator, is also chair of Concordia's Department of Physics and the Concordia University Research Chair in Nanoelectronics and Quantum Materials.Nature Communications is an open access, multidisciplinary journal dedicated to publishing research in biology, physics, chemistry and earth sciences."We have shown experimentally that we can control whether or not positively and negatively charged particles behave the same way in very short carbon nanotube transistors.
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Dr. Jennifer Ludwig of the Technical University of Munich (TUM) has developed a process that allows a fast, simple, and cost-effective production of the promising cathode material lithium cobalt phosphate in high quality.Hope is pink: The powder that Jennifer Ludwig carefully pours into a glass bowl and which glows pink in the light of the laboratory lamp has the potential to significantly improve the performance of future batteries."Lithium cobalt phosphate can store substantially more energy than conventional cathode materials," explains the chemist.Working in the group of Tom Nilges, head of the Professorship of Synthesis and Characterization of Innovative Materials, the chemist has developed a process for producing the pink powder quickly, with minimal amounts of energy and in the highest quality.It operates at higher voltages than the traditionally employed lithium iron phosphate and thus, attains a higher energy density - 800 watt hours per kilogram instead of just under 600 watt hours.Previous process: expensive and energy-intensive
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Incorporating animation techniques from the film industry, the researchers developed a robust new modeling tool that could help spur new molecular discoveries.For a look behind-the-scenes, watch ACS' Headline Science video.The film starts with a black screen.Objects start flickering onscreen in the foreground, but instead of spacecraft hurtling toward a planet, it's sperm racing to be the first to fertilize the blue egg.Donald Ingber and Charles Reilly created the short film to broaden public interest in science.But in doing so, they unexpectedly developed a useful tool for modeling molecular behavior.
The investigators discovered that treating a complex oxide crystal with either heat or chemicals caused different atoms to segregate on the surface, i.e., surface reconstruction.Then you don't need costly and energy-intensive downstream chemical separation as much."The researchers surveyed four catalysts of perovskite, a mixed oxide crystal made of cubic unit cells of the atomic composition ABO3, with A as a rare-earth metal cation (positively charged ion), B as a transition-metal cation and O as oxygen.Treating a perovskite with heat resulted in a catalyst with more A atoms on its surface, scientists including first co-authors Guo Shiou Foo and Felipe Polo-Garzon reported in ACS Catalysis.The scientists were the first to systemically study how different perovskite surface compositions affect acid-base catalysis.The knowledge gained could provide a route to selective conversion of biomass into value-added chemicals.
(Millbrook, NY) With support from a $1.47 million grant from the National Aeronautics and Space Administration (NASA), an interdisciplinary team of researchers from the Cary Institute of Ecosystem Studies, Dartmouth, and the University of New Hampshire are developing high-tech tools to monitor cyanobacteria in lakes, predict impending blooms, and identify factors that are degrading water quality.Blooms disrupt recreation and can produce toxins that are harmful to fish and people.Under the three-year grant, the research team will explore how population growth, land use, climate change, and lake-specific factors have affected water quality in approximately 2,000 lakes in New York, Vermont, New Hampshire, and Maine.To identify patterns and understand relationships between these complex systems, the team will bring together multiple data types collected via satellite, drone, and mobile app.Kathleen Weathers, an ecosystem ecologist at the Cary Institute of Ecosystem Studies and co-principal investigator on the study explains, "NASA funding will allow us to tap into the power of both remote sensing and citizen science to better understand, predict, and manage cyanobacterial blooms, which are becoming a real problem in Northeast lakes.David Lutz, an environmental scientist at Dartmouth and the study's principal investigator notes, "There has been a great deal of research focusing on cyanobacterial blooms in the Midwest and southern states, where nutrient pollution is abundant due to runoff from fertilizer applied to agricultural fields.
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But could someone use mobile advertising to learn where you go for coffee?Could a burglar establish a sham company and send ads to your phone to learn when you leave the house?New University of Washington research, which will be presented Oct. 30 at the Association for Computing Machinery's Workshop on Privacy in the Electronic Society, suggests that for roughly $1,000, someone with devious intent can purchase and target online advertising in ways that allow them to track the location of other individuals and learn what apps they are using."Anyone from a foreign intelligence agent to a jealous spouse can pretty easily sign up with a large internet advertising company and on a fairly modest budget use these ecosystems to track another individual's behavior," said lead author Paul Vines, a recent doctoral graduate in the UW's Paul G. Allen School of Computer Science & Engineering.The research team set out to test whether an adversary could exploit the existing online advertising infrastructure for personal surveillance and, if so, raise industry awareness about the threat."We are sharing our discoveries so that advertising networks can try to detect and mitigate these types of attacks, and so that there can be a broad public discussion about how we as a society might try to prevent them."
The growth in 3-D printing is allowing manufacturers to reduce production time and save money.But the predicted mass production of 3-D printed products for consumers has not yet come to pass.An article in Chemical & Engineering News (C), the weekly newsmagazine of the American Chemical Society, explains how industry is using the technology.Over the past decade, 3-D printing has been portrayed as the next big manufacturing trend, and companies are now starting to take advantage of the technology.For example, as C Senior Correspondent Alexander Tullo reports, Volkswagen has started using 3-D printers for tools and parts, which has saved the company time and hundreds of thousands of dollars.Others are also getting on board, spurring global sales of 3-D printing equipment and related materials to grow to $2.7 billion last year.
Sprawling mining operations in Brazil are destroying much more of the iconic Amazon forest than previously thought, says the first comprehensive study of mining deforestation in the world's largest tropical rainforest.The research, published in Nature Communications, finds that mining-related forest loss caused roughly 10 percent of all Amazon deforestation between 2005 and 2015, much higher than previous estimates."These results show that mining now ranks as a substantial cause of Amazon forest loss," says Laura Sonter of UVM's Gund Institute for Environment."Previous estimates assumed mining caused maybe one or two percent of deforestation.Hitting the 10 percent threshold is alarming and warrants action."Built by mining companies or developers, these routes also enable other forms of deforestation, including agriculture, which remains the leading cause of Amazon forest loss.
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(BOSTON) -- Like many other scientists, Don Ingber, M.D., Ph.D., the Founding Director of the Wyss Institute, is concerned that non-scientists have become skeptical and even fearful of his field at a time when technology can offer solutions to many of the world's greatest problems."I feel that there's a huge disconnect between science and the public because it's depicted as rote memorization in schools, when by definition, if you can memorize it, it's not science," says Ingber, who is also the Judah Folkman Professor of Vascular Biology at Harvard Medical School and the Vascular Biology Program at Boston Children's Hospital, and Professor of Bioengineering at the Harvard Paulson School of Engineering and Applied Sciences (SEAS).To see if entertainment could offer a solution to this challenge, Ingber teamed up with Charles Reilly, Ph.D., a molecular biophysicist, professional animator, and Staff Scientist at the Wyss Institute who previously worked at movie director Peter Jackson's Park Road Post film studio, to create a film that would capture viewers' imaginations by telling the story of a biological process that was accurate down to the atomic level."Applying an artistic process to science frees you from the typically reductionist approach of analyzing one particular hypothesis and teaches you a different way of observing things.The patterns and mechanics of sperm swimming have been studied and described in scientific literature, but visually showing the accurate movement of a sperm tail required tackling one of the toughest challenges facing science today: how to create a multi-scale biological model that maintains accuracy at different sizes, from cells all the way down to atoms.That would be like starting with the Empire State Building and then zooming in close enough to see every individual screw, nut and bolt that holds it together, as well as how individual water molecules flow inside its pipes, while maintaining crystal-clear resolution - not an easy task.
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This involves the use of membranes: filters that stop the methane and let the CO2 pass through.Researchers at KU Leuven (University of Leuven), Belgium, have developed a new membrane that makes the separation process much more effective.Natural gas, for instance, always contains quite a bit of carbon dioxide (the greenhouse gas CO2), sometimes up to 50 percent.The methane can then be used as a source of energy for heating, for the production of chemicals, or as fuel, while the CO2 can be reused as a building block for renewable fuels and chemicals.Existing membranes still need to be improved for effective CO2 separations, says Professor Ivo Vankelecom from the KU Leuven Faculty of Bioscience Engineering.The commercially available membranes come with a trade-off between selectivity and permeability: they are either highly selective or highly permeable.
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Water-repellent surfaces and coatings could make ice removal a literal breeze by forcing ice to grow up rather than just skate by, says a new study from the University of Nebraska-Lincoln and several Chinese institutions.The researchers discovered that ice grows differently on absorbent vs. water-repellent surfaces, demonstrating that a gust of air can blow away ice that forms on the latter.Their findings suggest that applying water-repellent coatings to windshields before winter storms - or engineering surfaces that inherently repel water - could enable a strong breeze to handle the burden of ice removal.Molecular-level simulations suggested that these droplets almost immediately began forming two stacked layers of hexagonal 2-D ice, a form that Zeng previously discovered and dubbed Nebraska Ice.This ultra-thin ice encourages water molecules to essentially skate across it and colonize other areas of the surface, Zeng said.In the winter, if you have that kind of ice on a windshield, you have to use a scraper to get it off."
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Oracle opens its bulletin with news that it "... continues to periodically receive reports of attempts to maliciously exploit vulnerabilities for which Oracle has already released fixes.""In some instances, it has been reported that attackers have been successful because targeted customers had failed to apply available Oracle patches.Oracle therefore strongly recommends that customers remain on actively-supported versions and apply Critical Patch Update fixes without delay."With puny humans failing it, no wonder Big Red's talking autonomous databases that patch themselves.Back to the bug news, which tells us Oracle Fusion Middleware has 38 vulns, while 37 turned up in Hospitality Applications and another 25 in MySQL.Many of the bugs hit multiple products: CVE-2016-6814, for example, is inherited from Apache Groovy, and is present in Oracle Database Server, the Construction and Engineering Suite, Enterprise Manager Grid Control, Oracle Fusion Middleware, Health Sciences Applications, and two Retail Applications components.
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