In a step toward accelerating the production of new gene therapies, scientists report in ACS Nano that they have developed remote-controlled, needle-like nanospears capable of piercing membrane walls and delivering DNA into selected cells.They say the new technique, which can ferry biological materials to cells with pinpoint accuracy, overcomes many of the existing barriers to effective gene modification.Medical interventions based on the use of genetically modified cells are an emerging area of stem cell and cancer immunology research.Existing approaches to delivering DNA into cells for producing these gene therapies include viruses, external electrical fields or harsh chemical reagents.Researchers have experimented with sharp-tipped nanoparticles stuck on surfaces to deliver biomolecules to cells, but it is difficult to remove the modified cells from the nanoparticle-coated surface for further study.Self-propelled nanoparticles also can deliver molecules to cells in the body.
Important biological differences between men and women exist - right down to the cellular level.Investigators from Brigham and Women's Hospital and colleagues at Stanford University, McGill University and University of California, Berkeley wanted to determine if differences between male versus female cells may influence how well cells uptake nanoparticles - a key vehicle for imaging and targeted drug delivery applications.The team demonstrated that cell sex considerably influenced cellular uptake of nanoparticles and found that cells from men and women responded differently to reprogramming techniques used to enhance the ability of the cells to differentiate into a greater variety of cell types.Their results, published this week in ACS Nano, may help researchers more safely and effectively produce nanomedicines that take sex into account.Different responses of male and female cells to the exact same type and concentration of nanoparticles is the latest overlooked factor we have found."In the body, cells are awash in a wide range of biomolecules including paracrine factors, which are small proteins that can interact with the surface of nanoparticles.
Using a microfluidic platform that connects engineered tissues from up to 10 organs, the researchers can accurately replicate human organ interactions for weeks at a time, allowing them to measure the effects of drugs on different parts of the body."Some of these effects are really hard to predict from animal models because the situations that lead to them are idiosyncratic," says Linda Griffith, the School of Engineering Professor of Teaching Innovation, a professor of biological engineering and mechanical engineering, and one of the senior authors of the study.David Trumper, an MIT professor of mechanical engineering, and Murat Cirit, a research scientist in the Department of Biological Engineering, are also senior authors of the paper, which appears in the journal Scientific Reports.When developing a new drug, researchers identify drug targets based on what they know about the biology of the disease, and then create compounds that affect those targets."Animals do not represent people in all the facets that you need to develop drugs and understand disease," Griffith says.To achieve this, the researchers needed new equipment -- a platform that would allow tissues to grow and interact with each other -- as well as engineered tissue that would accurately mimic the functions of human organs.
The system, created by a team from Imperial College London, encapsulates biological cells within an artificial cell.Using this, researchers can harness the natural ability of biological cells to process chemicals while protecting them from the environment.This system could lead to applications such as cellular 'batteries' powered by photosynthesis, synthesis of drugs inside the body, and biological sensors that can withstand harsh conditions.Previous artificial cell design has involved taking parts of biological cell 'machinery' - such as enzymes that support chemical reactions - and putting them into artificial casings.In the proof-of-concept experiment, the artificial cell systems produced a fluorescent chemical that allowed the researchers to confirm all was working as expected.Lead researcher Professor Oscar Ces, from the Department of Chemistry at Imperial, said: "Biological cells can perform extremely complex functions, but can be difficult to control when trying to harness one aspect.
Meanwhile, our endlessly rising energy needs and use of heavy metals in industrial processes have maximized our exposure to toxic materials in water.Current commercial methods to remove heavy metals including lead from municipal drinking water tend to be costly and energy-consuming, without being sufficiently efficient.Less conventional approaches might be more efficient, but are single-use, difficult to regenerate, or produce significant toxic waste as a side-product.Now, the lab of Professor Wendy Lee Queen at EPFL, with colleagues at the University of California Berkeley and Lawrence Berkeley National Laboratory have found a solution using metal organic frameworks (MOFs), which are materials made up of metal nodes interlinked by organic chemical 'struts'.Their unprecedented internal surface areas and easy chemical tunability allow MOFs to "pull" water vapor and other gases from air.A PhD student at EPFL-Valais, Daniel T. Sun, has designed a water-stable MOF/polymer composite using cheap, environmentally and biologically friendly materials.
University of Melbourne research reveals that one in four Americans report chemical sensitivity, with nearly half this group medically diagnosed with Multiple Chemical Sensitivities (MCS), suffering health problems from exposure to common chemical products and pollutants such as insect spray, paint, cleaning supplies, fragrances and petrochemical fumes.The research was conducted by Anne Steinemann, Professor of Civil Engineering and Chair of Sustainable Cities from the University of Melbourne School of Engineering, and published in the Journal of Occupational and Environmental Medicine.Professor Steinemann is an international expert on environmental pollutants, air quality, and health effects.Professor Steinemann found the prevalence of chemical sensitivity has increased more than 200 per cent and diagnosed MCS has increased more than 300 per cent among American adults in the past decade.Across America, an estimated 55 million adults have chemical sensitivity or MCS."MCS is a serious and potentially disabling disease that is widespread and increasing in the US population," Professor Steinemann said.
This article originally appeared on 20th January 2016.Speaking to the Radio Times recently ahead of his BBC Reith Lecture, Hawking said that ongoing developments in science and technology are poised to create “new ways things can go wrong”.The scientist pointed to nuclear war, global warming, and genetically engineering viruses as some of the most serious culprits.“By that time we should have spread out into space, and to other stars, so it would not mean the end of the human race.He wasn't wrong to highlight these risks — but in terms of what we’re actually supposed to do about, his answers are frustratingly simplistic and opaque, in sharp contrast to his predictions of doom.That is why I asked the question.”
Do you think you have what it takes to engage in banter on a building site?If so, you might be interested in a promotion the government is running at the moment, where members of the public can tour building sites and infrastructure projects to get some sort of idea of what the work entails.It's about encouraging people to think of building and engineering as being more interesting careers than app development and serving coffee to people with MacBooks, with the country's roads manager Highways England giving potential road builders a look behind the scenes of five big projects.If you want to have a look around, some of the site tours are still taking bookings through the government's 2018 Open Doors web site, where you can book a guided bus tour around the A14 roadworks or enjoy the thrill of hearing about the works being done to the Oldbury Viaduct along the M5, plus there are plenty of other non-roads projects open for exploration, like the genuinely exciting opportunity to tour Galliford Try's Airbus wing facility, see some posh flats in London take shape, or watch the concrete being poured at the new Barbara Hepworth wing of the University of Huddersfield.
Rowan cites mega projects such as "quantum satellites and hypersonic gliders" as well as the daunting Chinese diligence: long hours and hard work.In the past, I've advised Western competitors to "be afraid" because of the skill of producing a better, or as good, product more cheaply, like this home IoT kit.In the 1980s, using identical language and reasoning to Rowan, policy nerds and opiniators were seized by another "Yellow Peril", a fear of Japan.Those brilliant STEM graduates can give you a competitive advantage in today's market, but for tomorrow's success, you need to take risks and create new markets.China's success today comes from mastering supply chains, from adding engineering excellence to an existing market.That combination has served them very well so far.
The research study of Global Engineering Resins, Polymer Alloys and Blends Market 2017-2022 offers a strategic valuation of this Industry.It enhances the top executive level key decision making capabilities by providing In-depth analysis comprising key market players, market forecasts, supply, demand, profit, latest market trends and production information.Ask for Report Brochure @ http://orbisresearch.com/contacts/request-sample/2093804The report contains qualitative and numerical valuation by top industry analysts in this industry, first-hand data along with their most recent verbatim and each industry manufacturers via the market value chain.The industry report focuses on the growth opportunities, which will help the Engineering Resins, Polymer Alloys and Blends Market to expand operations in the existing markets globally.The global Engineering Resins, Polymer Alloys and Blends Market report has been strategically curated to fulfil the needs of the customer through in-depth analysis of the Engineering Resins, Polymer Alloys and Blends Market that can assist the customer in gaining actionable insights regarding the Engineering Resins, Polymer Alloys and Blends Market.In this report, engineering resins include traditional varieties such as polyamides, polycarbonates, polyacetals, (reinforced) polyethylene terephthalate (PET) and polybutylene terephthalate (PBT); along with alloys/blends such as polycarbonate-ABS (PC/ABS), polyphenylene oxide/high-impact polystyrene (PPO-HIPS), polyphenylene oxide/polyamides (PPO/polyamide) and polycarbonate-PBT (PC/PBT).Higher-performance engineering resins covered include polysulfones, poly(phenylene-sulfide) (PPS), polyketones and liquid crystal polymers.The key applications covered include the automotive market segmented by under-the-hood, external and interior products; electronic/electrical markets; medical devices and products; building and construction materials; appliances; plastic rigid food packaging; and several key smaller markets, including optical lenses and aviation products.Engineering Resins, Polymer Alloys and Blends Market Report includes:An overview of the global market for engineering resins, along with polymer alloys and blendsAnalyses of global market trends, with data from 2016, estimates for 2017, and projections of compound annual growth rates (CAGRs) through 2022Segmentation of resins into a wide variety of applications as well as selected commodity thermoplastics and thermosetsDiscussion of the major materials involved in terms of plant capacities, markets by application, new technologies and products, and rationales for anticipated growthCoverage of key applications, including automotive segmented by under-the-hood, external and interior products; electrical/electronic markets; medical devices/products; building/construction materials; appliances; electronic enclosures; plastic rigid food packaging; and several key smaller markets such as optical lenses and aviation productsPurchase a single user copy @ http://orbisresearch.com/contacts/enquiry-before-buying/2093804Companies Mentioned in the Engineering Resins, Polymer Alloys and Blends Market Report :-ASAHI KASEI CHEMICALS CORP.BASF CORP.CELANESECHEVRON PHILLIPS CHEMICAL COMPANY LPCOVESTRODAICEL CORP.DSM ENGINEERING PLASTICSDUPONT INC.EASTMAN CHEMICALEMS GRIVORY.EVONIK INDUSTIRIS.LANXESS CORP.MITSUBISHI ENGINEERING PLASTICSMITSUI CHEMICALS AMERICA INC.SABIC INNOVATIVE PLASTICSSOLVAY SPECIALTY POLYMERS USA LLCTEIJIN KASEI AMERICA INC.TORAY PLASTICS (AMERICA) INC.VICTREX USA LTD.Major points from Table of Contents:List of TablesSummaryTable 1 : Summary Table: Global Engineering Resin/Polymer Alloy/Blend Market, by Resin Type, Through 2022Table 2 : Selected Physical Properties of Engineering PolymersTable 3 : Impact of Morphology on Engineering Resin PropertiesTable 4 : Selected Engineering Resin American Society of Testing Materials TestsTable 5 : Comparisons of Polyamide 6 and Polyamide 66 PropertiesTable 6 : Key Global Polyamide ProducersTable 7 : Global Polyamide Market, by Application, through 2022Table 8 : Global Polyamide Automotive Market, by Segment, through 2022Table 9 : Key Global Polycarbonate Producers and Trade-Named ProductsTable 10 : Global Polycarbonate Market, by Application, through 2022Table 11 : Global Polycarbonate Automotive Market, by Segment, through 2020Table 12 : Key Global Polycacetal Producers and Trade-Named Products, 2016Table 13 : Typical Polyacetal ApplicationsTable 14 : Global Polyacetal Market, by Application, through 2022Table 15 : Global Polyacetal Automotive Market by Segment, Through 2022Table 16 : Leading Global PET Producers, 2016Table 17 : Global Key PET Engineering Grade Producers and Trade Names, 2016Table 18 : Global Engineered PET Market, by Application, Through 2022Table 19 : Global Engineered PET Automotive Market, by Segment, through 2022Table 20 : Global PBT Market, by Application, through 2022Browse Full Engineering Resins, Polymer Alloys and Blends Market Report @ http://orbisresearch.com/reports/index/engineering-resins-polymer-alloys-and-blends-global-marketsAbout Us:Orbis Research (orbisresearch.com) is a single point aid for all your market research requirements.We have vast database of reports from the leading publishers and authors across the globe.We have complete information about our publishers and hence are sure about the accuracy of the industries and verticals of their specialization.
The research study of Global Agricultural Biotechnology Market 2017-2022 offers a strategic valuation of this Industry.It enhances the top executive level key decision making capabilities by providing In-depth analysis comprising key market players, market forecasts, supply, demand, profit, latest market trends and production information.Ask for Report Brochure @ http://orbisresearch.com/contacts/request-sample/2093789The study scope includes key agricultural biotechnology tools (i.e., next generation DNA sequencing, biochips, RNA interference, synthetic biology tools and genome editing tools); synthetic biology-enabled chemicals and biofuels; biotech seeds; and biologicals.BCC analyzes these technologies and products to determine present and future market sizes, and forecasted growth from 2017 through 2022.The report also discusses industry strategic alliances, industry structures, competitive dynamics, patent status, and market driving forces.The report contains qualitative and numerical valuation by top industry analysts in this industry, first-hand data along with their most recent verbatim and each industry manufacturers via the market value chain.The industry report focuses on the growth opportunities, which will help the Agricultural Biotechnology Market to expand operations in the existing markets globally.The global Agricultural Biotechnology Market report has been strategically curated to fulfil the needs of the customer through in-depth analysis of the Agricultural Biotechnology Market that can assist the customer in gaining actionable insights regarding the Agricultural Biotechnology Market.BCC provides in-depth coverage of the agricultural biotechnology industry structure, including genomics technology providers (e.g., genome editing, NGS, microarray companies); major seed companies; biotech traits companies; synthetic biology tools companies; companies developing plant feedstocks; and agricultural biologicals companies.It provides an in-depth analysis of major industry acquisitions and alliances during 2015 and 2016.Agricultural Biotechnology Market Report Includes:An overview of the global markets for agricultural biotechnology and related emerging technologiesAnalyses of global market trends, with data from 2015 and 2016, estimates for 2017, and projections of compound annual growth rates (CAGRs) through 2022Segmentation of the markets by product type (microarrays, DNA sequencing, biochips, synthetic biology-enabled and transgenic seeds), by crop type, and by geographyInformation on growth driving forces, market applications, industry structure and competitive dynamicsAnalysis of key technologies and products to determine the present and future status of the marketProfiles of major players in the industryPurchase a single user copy @ http://orbisresearch.com/contacts/enquiry-before-buying/2093789Companies Mentioned:ADVANTA LTD.AGBIOME LLCAGRELIANT GENETICS, LLCAGRISOMA BIOSCIENCES, INC.AGRIVIDAAPSE, LLC.ARBORGEN, INC.ARCADIA BIOSCIENCES, INC.ARYSTA LIFESCIENCE CORPORATIONBASF AGBAYER AGBENSON HILL BIOSYSTEMS INC.BGI SHENZHENBIOGEMMACARIBOU BIOSCIENCES INC.CELLECTIS SACERES, INC.CHROMATIN, INC.CIBUS, INC.DIVERSITY ARRAYS TECHNOLOGYDLF SEEDS AND SCIENCEDOW CHEMICAL COMPANYI.DU PONT DE NEMOURS AND COMPANYEVOGENE LTD.More listed……….Major points from Table of Contents:List of TablesSummary Table : Global Market For Agricultural Biotechnology, By Segment, Through 2022Table 1 : Scope Of The ReportTable 2 : Global Market For Agricultural Biotechnology, By Segment, Through 2022Table 3 : Agricultural Biotechnology Market Driving ForcesTable 4 : Life Cycle Status Of Agricultural Product SegmentsTable 5 : Impact Of New Technologies On Crop Productivity, 1860-2016Table 6 : Agricultural Biotechnology Industry Key Structural ComponentsTable 7 : Plant TechnologiesTable 8 : Advanced Plant Modification PlatformsTable 9 : Plant Modification Biotechnology ToolsTable 10 : Dna Sequencing TechnologyTable 11 : Dna Sequencing Technology In Agricultural BiotechnologyTable 12 : Biochips TechnologiesTable 13 : Biochip Technologies In Agricultural BiotechnologyTable 14 : Rna Interference TechnologyTable 15 : Rna Interference Technologies In AgricultureTable 16 : Barriers To Commercialization Of Rna Interference In AgricultureTable 17 : Genome Editing TechnologiesTable 18 : Comparison Of Gene Editing PlatformsTable 19 : Comparison Of Genetic Engineering And Synthetic BiologyTable 20 : Genetic Engineering/ Synthetic Biology Technology In Agricultural BiotechnologyTable 21 : Seed TypesBrowse Full Agricultural Biotechnology Market Report @ http://orbisresearch.com/reports/index/agricultural-biotechnology-emerging-technologies-and-global-marketsAbout Us:Orbis Research (orbisresearch.com) is a single point aid for all your market research requirements.
Jericho Capital says deal would benefit Dell alone, suggests VMware buy Red Hat insteadInvestment firm Jericho Capital Asset Management L.P has departed from its usual practice of not commenting publicly on deals by publishing a scathing letter addressed to VMware’s independent directors decrying a reverse merger between VMware and Dell.Jericho owns around 1.8 per cent of VMware, enough to make it a big investor but not enough that it must legally disclose its holding or to let it press for a seat on the board.But anyone can issue a press release and that’s how the firm’s letter appeared.The letter says Jericho felt “it is important to comment publicly at this time before Dell goes too far down the road in pursuit of a strategy that would effectively amount to a bailout of Dell and would be highly detrimental to VMW’s shareholders [VMW is VMware’s stock ticker].”“There is no doubt in our mind that a reverse merger of Dell into VMW would be a terrible deal for VMW shareholders,” the letter said.
As a high traffic outlet supporting editorial efforts, events, networking and resources with a three-person engineering team, we did our best to build on what we had in ways that were efficient.So, out of necessity, we figured out how to stretch the site we had in a million different ways.As anyone who has ever done a Goodwill run (or five) before a change of address knows, the best way to thoroughly clear up clutter is a fresh start.Additionally, a sizeable portion of our dedicated readers are technologists and product thinkers, who we knew would take notice of the choices that we made, and, hopefully, understand the process that we are going to go through for the next couple of years to make this thing great.Our premise was that reading an article should feel enjoyable, and that it should be frictionless and fun to get more context surrounding whatever you’re consuming, whenever you want it.Among other benefits, this ended the need for full page loads every time you want to read something new, opening up a new world of interaction possibilities, and for a reading experience where articles could increasingly relate to each other and to the broader context in which they emerge.
Netflix has detailed its latest hack day project, this one called “Netflix in Space.” As the name suggests, this project involves streaming Netflix in space, though the company didn’t send any actual engineers on the mission.Rather, the team used a helium balloon with a doomed iPhone and GoPro to prove that Netflix videos can play in space…or, at least, 115,000ft above Earth.The Netflix team behind the project detailed their work in a video published on the Netflix UI Engineering YouTube account.In it, we see a box composed of double-walled acrylic and a styrofoam cooler coupled with heaters and an avionics board.That board contains things like temperature, altitude, GPS, and pressure sensors to supply the team with info.Within the cooler, the engineers placed the GoPro camera for recording the event, plus an iPhone which was glued face-down to the acrylic window.
In a world first, Australian researchers have harnessed the power of diamonds in a breakthrough that could lead to radical improvements in the way human bodies accept biomedical implants.The development is the first step toward 3D printed diamond implants for biomedical uses and orthopaedics -- surgical procedures involving the human musculoskeletal system.While titanium offers a fast, accurate and reliable material for medical grade and patient-specific implants, our bodies can sometimes reject this material.The breakthrough has been made by biomedical engineer Dr Kate Fox and her team at RMIT's School of Engineering."Currently the gold standard for medical implants is titanium but too often titanium implants don't interact with our bodies the way we need them to," Fox said."To work around this, we have used diamond on 3D scaffolds to create a surface coating that adheres better to cells commonly found in mammals.
Before the Wi-fi and the Internet, the telephone and the telegraph, the original instant messaging services of society were homing pigeons.After becoming the first domesticated birds, for an estimated 2,000 years, these reliable messengers have brought news from battlefronts and between heads of state.Then, about 200 years ago, fanciers from Belgium created an international sporting sensation, breeding racing pigeons to have ever faster flights and longer homing skills.Nowadays, these birds can fly up to 1,000 kilometers from home at speeds up to 70 kilometers per hour, and the best of them fetch thousands of euros on the breeding market in a continual effort to one-up the competition.Recently, scientists have been using state-of-the art genomic tools to also help home in on the special traits of racing pigeons.The study also including looking at gene expression differences (using RNA sequencing expression data) in the brains and muscle tissue of racing pigeons versus other breeds.
Researchers at the Harvard John A. Paulson School of Engineering and Applied Sciences (SEAS) have developed a flat optical component that is simultaneously a metalens, a microscope objective that can resolve details smaller than a wavelength of light, and an optical vortex and hologram generator.Each functionality is controlled by a different wavelength of light."The breakthrough of this new flat optical device is that it can radically change its function based on the wavelength of light it reflects," said Federico Capasso, the Robert Wallace Professor of Applied Physics at SEAS and senior author of the research."In this research, we decoupled functions at different wavelengths," said Zhujun Shi, first author of the paper and graduate student at SEAS."Compared to previous flat optical devices, this device has an extra degree of freedom that you can tune at different wavelengths.The Harvard Office of Technology Development has protected the intellectual property relating to this project and is exploring commercialization opportunities.
ALBUQUERQUE, N.M. -- Spent nuclear fuel needs to be safely transported from the power plants where it is generated to interim storage locations and eventually to a permanent geologic disposal site.Late last year, Sandia researchers completed an eight-month, 14,500-mile triathlon-like test to gather data on the bumps and jolts spent nuclear fuel experiences during transportation.Nuclear power supplies almost 20 percent of U.S. electricity and is the leading carbon-neutral power source.However, it produces between 2,200 and 2,600 tons of spent fuel in the U.S. each year.This test is more realistic than past tests and could result in a more reliable quantification of the transportation risks," said Sylvia Saltzstein, manager of the transportation projects.Sandia collaborated on the triathlon with Equipos Nucleares S.A. (ENSA), the Spanish cask designer and manufacturer, and Empresa Nacional de Residuos Radiactivos S.A. (ENRESA), the corporation responsible for the management of nuclear waste in Spain.
The National Science Foundation has awarded Portland State University a three-year, $300,000 grant to help undergraduate student researchers use big data to guide growth in the Portland metropolitan region.PSU's "Computational Modeling Serving the City" project will bring eight college students to PSU from throughout the U.S. this summer to work on research projects involving transportation, pollution, water sources and other topics important to Portland's quality of life.The students will learn the fundamentals of computational modeling and then use it during an eight-week course to tackle real-world problems in the Portland area.The grant will enable PSU to recruit a diverse population of students across multiple disciplines.The program will target students at institutions with limited science, technology, engineering and math (STEM) research opportunities such as two-year community colleges.The award is a joint project with the Portland Institute for Computational Science, which will provide computing resources that will allow students to simulate large-scale computational models.
ORLANDO, Fla. – The wide variety of collaboration and communications tools now available to businesses can help connect employees in different locations, but can also result in fragmented and siloed conversations.With that in mind, a new breed of team collaboration chat apps has emerged in recent years that, in many cases, incorporate video and voice call functionality alongside text-based messaging.That means enterprise organizations can begin to consolidate some of their existing communication tools into a single platform deployed across the business, according to a panel of CIOs at the Enterprise Connect conference here in Orlando.Jason Kasch, CIO at Structural Group, a Maryland-based engineering and construction firm, said his company had previously used a range of applications to connect staffers – everything from Microsoft’s Yammer and Oracle Social Network to group text messaging platform GroupMe and Slack.“We had a bunch of different products where people were collaborating and the one piece that was missing was a central contact point,” Kasch explained.“If everyone was on a different platform, they didn’t have the ability to single point click to start a video conference or a conversation immediately.”