In 2013, renowned Boston Children's Hospital pain researcher Clifford Woolf, MB, BCh, PhD, and chemist Kai Johnsson, PhD, his fellow co-founder at Quartet Medicine, believed they held the key to non-narcotic pain relief.Quartet was founded on the premise that inhibiting BH4 production could prevent the progression of acute pain to chronic pain in millions of patients, without threat of addiction or tolerance.With solid human genetic data and chemical biology, plus $17 million in series A funding, Quartet looked primed for success.Now, however, a surprising discovery about BH4 will likely rekindle interest in the once-promising pathway and could have profound implications for treating autoimmunity and cancer.In today's Nature, Woolf and his team at Boston Children's Hospital, together with immunologists from the Institute of Molecular Biotechnology (IMBA) in Vienna report that BH4 also functions as a kind of immunological thermostat in the body, raising and lowering the activity levels of T cells.To transition to an activated state, T cells need higher levels of mitochondrial energy; to produce it, mitochondria need higher levels of iron.
Tesla is now taking orders for the Model 3 from customers in China, according to its website.Reuters was the first to report that Tesla is taking orders in China.Tesla CEO Elon Musk did say in a tweet Thursday that some deliveries to customers in China will probably begin in March, but “April is more certain.”Customers must place a deposit of 8,000 yuan, or about $1,153, to begin their booking, according to materials on Tesla’s China website.They are eventually invited to configure the car to their liking (items such as paint color and other features).Once they complete the car purchase agreement, the remaining amount is due.
It can be disheartening to see shoppers leave but don’t give up on them just yet.Through dynamic product ads, Facebook makes it easier for companies to retarget lost shoppers.Through this offering, companies can focus on the important part of re-engaging cart abandoners: the messaging.Below are four approaches on how you can retarget cart abandoners.Even adding the most minimal shipping charge of $5 can make a shopper question whether or not they’re going to finalize their purchase.Data shows that 35 percent of cart abandonments occur once shoppers see the shipping costs.
If geographies were companies, Silicon Valley and New York would be the incumbents — successful today and possibly impregnable — and, like all incumbents, their outsized advantages obscure significant vulnerabilities.The cities we visited represent a new breed of challenger to the geographic dominance of venture capital’s leading centers, who — if they can cover the table stakes — bring advantages the Valley may struggle to capture.It helps startups to bring people together with a range of life experiences, so places like Columbia, Charlotte, and Atlanta should be natural winners.Racial diversity, yes — anchored in part by the strong presence of historically black colleges and universities, of which we visited several — and also diversity of their economies.Atlanta has the third-most Fortune 500 companies of any city, and you need to go down to 11 before you get any two in the same industry.Many students we met were first-generation college kids, whose parents and grandparents learned to climb over the brick wall of racism and passed on that grit.
PayPal said today that it will cancel accounts used by far-right group the Proud Boys as well as multiple accounts from anti-fascist groups.The move will make it much harder for the groups to raise money online.The decision is the latest act of “de-platforming” by the tech industry, which has been grappling with how to effectively handle users that promote hateful or violent ideologies.The ban will include the Proud Boys account as well as an account used by its founder, Gavin McInnes, PayPal said.The company is also canceling accounts for Atlanta Antifa, Antifa Sacramento, and the Anti-Fascist Network.PayPal had previously canceled accounts for Antifa Philadelphia, Antifa Arkansas, Belfast Antifa, and Rose City Antifa.
BLCK VC, a new organization founded by Storm Ventures associate Frederik Groce and NEA associate Sydney Sykes meant to connect, engage and advance black venture capitalists, is ready for a new era in the industry.Their mission: Turn 200 black investors into 400 black investors by 2024.“We think of ourselves as an organization formed by black VCs for blacks VCs to increase the representation of black investors,” Sykes told TechCrunch.“You can look around and say ‘well, I know five black VCs,’ but you can also say this firm does not have a single black VC, they may not even have a single underrepresented minority … We want to make firms reckon with the fact that there is a racial diversity problem; there is a lack of black VCs and every firm should really care about it.”BLCK VC has been at work since the beginning of 2018, building and expanding a network of black investors in the San Francisco area, Los Angeles and New York.They seek to provide a community for black investors, a space for honest conversations and questions and a resource for VC firms looking to make more diverse hires.
T-Mobile has launched a new $50/month unlimited prepaid plan.The new offering is through T-Mobile Prepaid, not Metro by T-Mobile, and it’ll only be available for a limited time.The plan gives customers unlimited data on T-Mobile’s 4G LTE network, as well as unlimited talk and text, but there are a few big restrictions.Unlimited plans are popular again, but they’re not quite the same as unlimited options from years ago.Multiple carriers offer more than one “unlimited” variant, each at different price points, and each with certain restrictions or benefits not available on alternative unlimited options.That’s the case for T-Mobile’s limited time offer: $50/month prepaid for unlimited data, but with big limits on video resolution and tethering.
Visible from NASA's Aqua satellite revealed the extent of Tropical Storm Xavier into western Mexico from its position just off-shore from Mexico's Jalisco state.Tropical Depression Twenty-Five-E (25E) formed on Nov. 3 and strengthened in a tropical storm on by 11 p.m. EDT that day.Xavier has continued to hug the coast of western Mexico since it formed.On Nov. 4 a visible image from the Moderate Resolution Imaging Spectroradiometer or MODIS instrument aboard NASA's Aqua satellite showed an organized storm with a thick band of powerful thunderstorms circling the center.A Tropical Storm Warning means that tropical storm conditions are expected somewhere within the warning area.The National Hurricane Center noted at 11 a.m. EDT the center of Tropical Storm Xavier was located near latitude 18.5 degrees north and longitude 106.2 degrees west.
It's that time of year when record companies roll out box sets by their brightest stars.The Beatles White Album 2018 RemixThere were four Beatles – John Lennon, Paul McCartney, George Harrison, and Ringo Starr – and here on the White Album, more than any other of the band's albums you hear them as four individuals.One of the six CDs in the box set is called the Esher Demos, a collection of 27 acoustic demo songs recorded in George Harrison's home prior to the studio sessions.The box set features a 164 page hardcover book loaded with essays, session photos, track by track notes, and a lot more.I always loved the White Album, but I felt it showed early signs of the Beatles breakup.
Samsung’s 49-inch CHG90 ultrawide, released in fall of 2017, challenged everyone’s assumptions about how large a monitor should be.Or has Dell gone too far?The screen comes with two HDMI 2.0 ports, one DisplayPort 1.4, five USB 3.0 downstream ports, two USB 3.0 upstream ports, and one USB-C port.You’ll also find audio jack pass-through on the Samsung monitor, which the Dell lacks.The Samsung has far fewer USB ports, though, with one USB 3.0 upstream and two USB 3.0 downstream.The Ultrasharp 49 includes five tactile buttons which are clearly labeled, once touched, by on-screen icons.
The new iPad Pro is definitely the best tablet Apple has ever made, but it's still not perfect.In 2010, Apple cofounder Steve Jobs demonstrated the iPad's capabilities by sitting down on a big comfy chair with it, on stage in front of hundreds of people, and showing what it was like to read a book or browse the web on the iPad.The first iPad Pro, which launched in 2015, had a massive, 12.9-inch display and supported an Apple-made keyboard and a stylus, called Apple Pencil.Apple also added a ton of productivity features for the iPad in iOS 11 last year, including a dock, drag and drop, multi-tasking, and a way to get files from your main computer — very laptop-y features.But if that's the case, Apple needs to consider adding these two crucial features that would bring its tablet much more in line with other professional workstations.In 2014, Apple introduced iCloud Drive, which let you access your saved files across your iPhone, iPad, or Mac.
In a recent video interview with CNBC (embedded below) LinkedIn founder Reid Hoffman says that one thing he would like to see more of in Silicon Valley is people assisting startup communities in other parts of the country.“We want more areas in the U.S. and the world to be entrepreneurial hot houses where they’re growing lots of interesting, entrepreneurial companies,” Hoffman told CNBC.“There are people in Silicon Valley doing that, I just want more of them.”The idea of bridging the gap between Silicon Valley and the rest of the country is something we talk about a lot here in the Heartland Tech section.And I’ve seen some progress on that front in the past year — from the “Comeback Cities” tour to a notable array of Silicon Valley LPs investing in last year’s “Rise of the Rest” seed fund.But I think it’s time to further the conversation from “how do we get more people in Silicon Valley to work with startup communities in other parts of the country” to “what kind of assistance do we need from them?” I worry that Silicon Valley investors will think that they’ve done their job of caring enough about the Heartlandsimply if they fly in to judge a few pitch competitions, or write a few angel checks.
Chip maker Flex Logix today introduced its new Nmax general purpose neural inferencing engine designed for AI deployment in a number of environments with popular machine learning frameworks like TensorFlow or Caffe.Multiple neural accelerators can be grouped together to achieve higher levels of throughput.Flex Logix says configurations of its Nmax 512 tiles can outperform other datacenter inferencing products like the Nvidia Tesla T4 when processing batches from image classification benchmark ResNet50.The accelerator was also made to carry out real-time detection of multiple objects with offerings like YOLOv3 to meet growing demand for visual processing on the edge.“With our architecture, since we load weights very quickly, we get high performance even if batch size equals one, so we’re good in the datacenter but we’re excellent at the edge,” Flex Logix CEO and cofounder Geoff Tate told VentureBeat in a phone interview.The Nmax series made its debut today at the Linley Processor Conference in Santa Clara, California.
Riding high on the launch of its iPhone XS and iPhone XR, Apple announced the much-anticipated iPad Pro 2018 today.With two screen sizes, two connectivity options and four storage capacities, separating specs get confusing fast.Double that when you compare the new iPad Pros to last year's models (which are no longer on sale) and to the regular iPad, which you can still buy.Luckily, the chart below will help you break down what's new and different.The iPad Pro for 2018 is a notable upgrade that embraces a rounded-corner design, ditches the home button for Face ID (like the iPhone) and yanks out Apple's proprietary Lightning connector port in favor of USB-C. That means you'll be able to use the iPad Pro to easily connect to other devices, like a DSLR camera.You'll also be able to charge your phone using the iPad's battery reserves, a feature within the USB-C standard.
The OnePlus 6T is the latest, and possibly the best, smartphone yet from the upstart China-based phone maker.It has the biggest display of any OnePlus phone at 6.41-inches, along with features like an in-display fingerprint sensor, a large 3,700mAh battery with excellent battery life and support for the CDMA network on Verizon Wireless.With a phone that has all of those features, owners will likely want to protect the OnePlus 6T from scratches, falls and accidental spills.It is also designed to offer owners superior shock absorption and drop resistance for the OnePlus 6T.OnePlus also sells a series of OnePlus 6T bumper cases for added shock absorbing protection, thanks to its thermoplastic polyurethane material.The cheapest is the nylon case, with a fine woven texture that costs $24.95.
Google today updated Firebase, its service for helping developers build apps for Android, iOS, and the web.Firebase has gained paid enterprise-grade support, ML Kit Face Contours, a Firebase Management API, Test Lab for iOS, Performance Monitoring improvements, and Firebase Predictions.The announcements were made at the third annual Firebase Summit in Prague, where Google also noted that over 1.5 million apps are actively using Firebase every month.All of today’s updates are aimed at helping enterprise developers build better apps, improve app quality, and grow their app business.If you already have a paid support package, you will be able to get your Firebase questions answered through the support console.Available in beta by the end of this year, Firebase support will be included at no additional charge with paid Google Cloud Platform support packages.
Lucasfilm president Kathleen Kennedy reportedly confirmed Thursday that development of an oft-rumored Boba Fett standalone film has come to an end.Her remarks, reported earlier by Sirus XM's Erick Weber, simultaneously confirmed the project was being worked on and marked its death.Instead, focus is being shifted to the upcoming series The Mandalorian, which will premiere exclusively on Disney's yet-unnamed streaming service.The series is helmed by Iron Man director Jon Favreau, along with an intriguing set of other directors, and focuses on a mysterious individual inspired by Boba Fett.The Star Wars franchise has been in flux since the disappointing box office returns of the spin-off film "Solo."Though LucasFilm has rejected reports that all spin-offs have been put on hold, reports have surfaced that the studio is reevaluating its approach to films beyond the new trilogy, which will come to an end with the upcoming Star Wars: Episode 9, scheduled for release Dec. 20, 2019.
Italiens konkurrensmyndighet bötfäller Apple och konkurrenten Samsung Electronics för att de använt mjukvaror för att göra mobiltelefoner långsammare.Böterna uppgår till 5 miljoner euro (drygt 50 miljoner kronor) för vart och ett av bolagen.För Apple blir det ytterligare 5 miljoner euro i böter sedan bolaget inte gett kunder tydlig information om hur de ska hantera eller eventuellt ersätta batterier i mobiltelefoner.Böterna kommer sedan konsumentorganisationer i Italien klagat på att mobiltillverkarna använder uppdateringar av mjukvaror för att försämra mobiltelefonernas funktion och därmed tvinga kunder att köpa nya telefoner.Apple bekräftade i fjol att mjukvaror i deras Iphone-telefoner haft en inbromsande effekt på mobiltelefoner med batteriproblem.De har däremot dementerat att de ska ha gjort något för att förkorta livslängden på mobiltelefonerna.
In an interview with BuzzFeed News, Apple CEO Tim Cook called on Bloomberg to retract its story alleging that Chinese spies compromised a company server through the use of malicious microchips.It’s the first time Cook has gone on the record to contest the allegations.There’s no truth to this,” Cook said in the interview.The initial Bloomberg report alleged that Chinese spies were able to infiltrate critical tech infrastructure belonging to companies like Apple and Amazon by injecting tiny microchips inside Supermicro servers.Allegedly, these hardware manipulations allowed the Chinese government backdoor access into computer networks run on those servers.Quickly after the report’s publication, Apple released a statement picking the story apart, denying each individual claim.