A team of researchers including Northwestern Engineering faculty has expanded the understanding of how virus shells self-assemble, an important step toward developing techniques that use viruses as vehicles to deliver targeted drugs and therapeutics throughout the body.By performing multiple amino acid substitutions, the researchers discovered instances of epistasis, a phenomenon in which two changes produce a behavior different from the behavior that each change causes individually."We found occurrences where two separate single amino acid changes caused the virus shell to break or become really unstable, but making both changes together produced a stable structure that functioned better than ever," said Danielle Tullman-Ercek, associate professor of chemical and biological engineering at the McCormick School of Engineering.The paper titled "Experimental Evaluation of Coevolution in a Self-Assembling Particle," was published the March 19 print issue of Biochemistry.Tullman-Ercek served as the paper's co-corresponding author along with collaborator Matthew Francis, professor of chemistry at the University of California at Berkeley.The work builds on past research in which Tullman-Ercek and collaborators developed a new technique, called SyMAPS (Systematic Mutation and Assembled Particle Selection), to test variations of a protein used by a bacterial virus called the MS2 bacteriophage.
Just imagine the fanfiction now.It’s also what Potterverse creator J.K. Rowling said to a shocked Carnegie Hall in 2007, moments after she revealed that she’d “always thought of” Albus Dumbledore, high wizard of Hogwarts, as gay.These days, Rowling’s social-justice-flavored extratextual canonical embellishments—not only about Dumbledore’s sexuality, which she elaborated on over the weekend, but also about Hermione’s race, Harry’s views on Israel, and Nagini’s hidden origins as a cursed Asian woman trapped in the body of a snake kept as a pet by a white supremacist—are mostly met with boos.Over the past decade-plus, Rowling seems to have lost touch with, if not downright alienated, the portion of the internet she hopes to engage with and delight with her cutesy, random-seeming new factoids.You may not be a fanfiction writer or reader or even a Potterhead, but you almost certainly dive into some fictional world on occasion, and those dives are likely longer and deeper than they used to be.Movie studios and companies like Netflix have become experts in stretching your attention: optimizing a show’s bingeability, engineering viral moments and social media speculation, leaning into easter eggs and online exclusives, buying up superfranchises so vast and rich you can make an unlimited numbers of books, movies, TV shows, videogames, VR experiences, and theme park rides out of them.
Raytracing explained: Nvidia, Microsoft lead the way in revolutionizing gaming graphicsMicrosoft announced DirectX raytracing a year ago, promising to bring hardware-accelerated raytraced graphics to PC gaming.In August, Nvidia announced its RTX 2080 and 2080Ti, a pair of new video cards with the company's new Turing RTX processors.These cards were the first, and currently only, cards to support DirectX Raytracing (DXR).That's going to change in April, as Nvidia has announced that 10-series and 16-series cards will be getting some amount of raytracing support with next month's driver update.Specifically, we're talking about 10-series cards built with Pascal chips (that's the 1060 6GB or higher), Titan-branded cards with Pascal or Volta chips (the Titan X, XP, and V), and 16-series cards with Turing chips (Turing, in contrast to the Turing RTX, lacks the extra cores for raytracing and machine learning).
On episode 88 of Digital Trends Live, hosts Greg Nibler and Drew Prindle ventured into the world of tech news in search for the biggest stories.The topics on today’s episode include Apple’s surprising reveals of a new iPad Air and iPad Mini, the New York Times report on Apple’s upcoming TV service, and the 2020 Olympics in Tokyo getting some assistance from robots.Later in the show, they spoke with Michael Holton, television studio analyst for the Portland Trail Blazers.The subject of the day was March Madness, the tournament that caps off the college basketball season.Holton talked about his own experience playing in the tournament, the factors he looks at when making his bracket predictions, and the rise of artificial intelligence programs that predict the tournament results with startling accuracy.
The new iPad Mini 5 brings updated internal hardware, but otherwise it’s identical to its predecessor, the iPad Mini 4, so the same cases will fit both tablets.If you are primarily seeking a keyboard for your iPad Mini, then Brydge has got you well and truly covered.The hinge rotates a full 180 degrees, so you can set the angle you want.Urban Armor Gear Folio CaseIf you want something protective and practical for your iPad Mini 4 or 5, then look no further.This sleek case is practical and stylish.
MoviePass released details of its new unlimited plan, "MoviePass Uncapped," on Tuesday.It will offer two price points for the unlimited plan: $119.40 up front for a year subscription or $14.95 month to month (increasing to $19.95 after an unspecified promo period).Business Insider reported on Monday that the upcoming unlimited plan was a source of internal turmoil at the startup.On Tuesday, MoviePass released details of its new unlimited plan, "MoviePass Uncapped."MoviePass says there will be "no cap on the number of 2D movies subscribers can see in MoviePass' theater network," but that it can throttle a subscriber's access at its discretion.MoviePass will offer two price points for the unlimited plan: $119.40 up front for a year subscription or $14.95 month to month (which will go up to $19.95).
(Millbrook, NY) In the Americas, primate species likely to harbor Zika - and potentially transmit the virus - are common, abundant, and often live near people.Lead author Barbara Han, a disease ecologist at Cary Institute, explains: "When modeling disease systems, data gaps can undermine our ability to predict where people are at risk.Globally, only two primate species have been confirmed positive for Zika virus.We were interested in how a marriage of two modeling techniques could help us overcome limited data on primate biology and ecology - with the goal of identifying surveillance priorities."Primate species in the Americas with Zika risk scores over 90% included: the tufted capuchin (Cebus apella), the Venezuelan red howler (Alouatta seniculus), and the white-faced capuchin (Cebus capucinus) - species adapted to living among people in developed areas.Also on the list: white-fronted capuchins (Cebus albifrons), commonly kept as pets and captured for live trade, and spider monkeys (Saimiri boliviensis), which are hunted for bushmeat in parts of their range.
Scientists from the National University of Science and Technology "MISIS" developed nanomaterial, which will be able to rstore the internal structure of bones damaged due to osteoporosis and osteomyelitis.Such diseases as osteoporosis and osteomyelitis cause irreversible degenerative changes in the bone structure.Such diseases require serious complex treatment and surgery and transplantation of the destroyed bone marrow in severe stages.Research group from the National University of Science and Technology "MISIS" (NUST MISIS), led by Anton Manakhov (Laboratory for Inorganic Nanomaterials) developed material that will allow to restore damaged internal bone structure without bone marrow transplantation.It is based on nanofibers of polycaprolactone, which is biocompatible self-dissolvable material.Earlier, the same research group has already worked with this material: by adding antibiotics to the nanofibers, scientists have managed to create non-changeable healing bandages.
Universidad Carlos III de Madrid (UC3M) and the IMDEA Networks Institute, in collaboration with the International Computer Science Institute (ICSI) at Berkeley (USA) and Stony Brook University of New York (USA), have carried out a study that encompasses 82,000 pre-installed apps in more than 1,700 devices manufactured by 214 brands, revealing the existence of a complex ecosystem of manufacturers, mobile operators, app developers and providers, with a wide network of relationships between them.Many of the pre-installed apps facilitate access to privileged data and resources, without the average user being aware of their presence or being able to uninstall them.The study shows, on the one hand, that the permission model on the Android operating system and its apps allow a large number of actors to track and obtain personal user information.These results are detailed out in an article that will be made public on April 1 and which will be presented at one of the main cybersecurity and privacy conferences worldwide, the 41st IEEE Symposium on Security and Privacy, California (USA) under the title An Analysis of Pre-installed Android Software.The Agencia Española de Protección de Datos- AEPD (Spanish Data Protection Agency), which has contributed to the dissemination of this study because of the massive impact of the results on citizen privacy, will present the results before the European Commission for Data Protection.In addition to the standard permissions defined in Android and that can be controlled by the user, the researchers have identified more than 4,845 owner or personalized permissions by different actors in the manufacture and distribution of the terminals.
When you think of ways to play big-name video games, you probably think of Microsoft's Xbox, Sony's PlayStation or Nintendo's Switch.The tech giant is expected to announce a new streaming game service at a press event during the Game Developers Conference in San Francisco on Tuesday.Google already showed off the service running Ubisoft's Assassin's Creed Odyssey during a public test late last year.And on Monday, the company showed off a new squiggle (or "s"?), which appears to be the likely logo for the streaming service.The service allows gamers to play standard PC games within Google's Chrome browser.
Ironman race events will continue to swim, bike and run to their exclusive digital home on Facebook Watch following a multiyear extension of the agreement between Ironman parent Wanda Sports Holdings and the social network.Facebook Watch will be the exclusive digital home for 17 live events this year, 19 in 2020 and 22 in 2021 under a third-year option in the pact, and full live coverage of the Ironman World Championship and Ironman 70.3 World Championship is included.There will also be video-on-demand recaps available for all events livestreamed via Facebook Watch.The schedule will be announced in the coming weeks, and all of the event broadcasts will be available globally via the Ironman Now Facebook page.Ironman will produce the livestreams specifically for Facebook Watch, incorporating interactive features such as Watch Parties, real-time polls, fan discussions and user-generated content from spectators along the course.Broadcasts will be hosted by past event champions including Dede Griesbauer, Rachel Joyce, Matt Lieto and Michael Lovato, as well as past World Champions and Hall of Famers Paula Newby Fraser and Greg Welch.
关于打击微信个人非法信贷贷类行为的公告 – WeChat Security CenterWhat happened: China’s most used messaging app, WeChat, has shut down over 2,500 user accounts and more than 1,000 group chats since the beginning of the year over illegal credit and loan activities, according to an announcement posted on the official account of WeChat Security Center.Why it’s important: The move is a response to the recent complaints from WeChat users about increasingly prevalent illegal lending behavior, and is part of a wider crackdown on illicit activities in the messaging app.Earlier this month, WeChat made a similar announcement announcing its progress on the sale of illegal and contraband products.Online lending has experienced rapid growth in China in recent years, but the sector is rife with fraud and illegal activities, largely due to a lack of oversight.WeChat, which has become a hotbed for fraud, has been trying to curb such behaviors especially as authorities tighten rules on online lending.
Their celebrity often obscures the work—humbler, less heroic, but often no less essential to the maintenance of a life—performed by those organs only doctors know about: the body’s back-up players, pulsing and pumping in relative obscurity.Not to mention the mid-tier organs, like the gallbladder, whose functions most of us only dimly comprehend, unless—or until—they start acting up.Professor of Biology and Medical Science at Brown University and head of the Brainerd Lab, which integrates studies of anatomy, physiology and biomechanics toward a more complete understanding of vertebrate morphology and evolutionThe first organ I’d give up would be the gallbladder.Gallbladder removal (due to gallstones) is one of the most common surgeries, and people do fine without a gallbladder.After that I’d go with the spleen, which is part of the lymphatic system of the body and helps fight infections.
So why don’t we have pain medicines designed just for men or women?Drug development begins with studies on rats and mice, and until three years ago, almost all that research used only male animals.Although they are remarkably effective in relieving the sudden pain of a broken bone or pulled tooth, they don’t work as well for people with persistent pain that lasts three months or longer.Some 50 million people struggle with pain most days or every day, and chronic pain is the leading cause of long-term disability in the United States.Women are more likely than men to have a chronic pain condition, such as arthritis, fibromyalgia, or migraines.About 17,000 people die each year from prescribed opioids as clinicians write almost 200 million opioid prescriptions, or more than one for every two American adults.
Jensen Huang, Nvidia’s CEO, paraded a range of goodies for GPU nerds, including a forthcoming credit-card sized AI computer board and software updates for its CUDA platform, during his company's annual GPU Technology Conference (GTC) in Silicon Valley on Monday.In fact, a good amount of it was stuff previously announced, and upstaged by Intel's earlier announcement that it was, as expected, building America's first exascale supercomputer using its own GPUs and CPUs.The board contains a 128-core Nvidia Maxwell GPU to accelerate neural network algorithms and similar mathematics, and a quad-core ARM Cortex-A57 CPU cluster for running application code.They're both set to compete against Google's AI-focused $150 (£113) TPU-based dev board, which finally went on sale earlier this month, and similar kit.It's supported by Amazon Web Services, Microsoft Azure, and Google Cloud, in that you can use the libraries to harness GPU hardware in those clouds.Mellanox CEO Eyal Waldman, who recently saw his silicon craftshop gobbled up by Nvidia for the princely sum of $6.9bn, was on hand during Huang's three-hour keynote to voice his support for his new overlords.
Beijing-based Bytedance has acquired 100 percent of Shanghai-based mobile game developer Mokun Technology as the world’s most valuable unicorn makes a further foray into gaming.Mokun, founded in 2013, recently became wholly owned by Beijing Zhaoxi Guangnian Technology, a subsidiary of Bytedance, according to public business registration information.Mokun’s executive chairman is currently Zhang Lidong, senior vice president and legal representative at Bytedance.The gaming company was previously owned by 37 Interactive Entertainment, a Shenzhen-listed game developer.Last month, Bytedance posted a job opening for a games content operator, based in Beijing, on its official career page.Mokun has developed a three-dimensional mobile game with a classical theme of the Three Kingdoms, a period in China’s history when it was divided between the states of Wei, Shu, and Wu.
Sony's animated Spider-Man: Into the Spider-Verse just won an Oscar for best animated feature.While it's still playing in some theaters, you can now watch this Oscar-winning movie at home on Digital HD and Blu-ray.Disclaimer: CNET may get a share of revenue from the sale of products featured on this page.The film that's chock-full of Spider-people -- including Miles Morales (Shameik Moore), Peter Parker (Jake Johnson) and Gwen Stacey (Hailee Steinfeld) -- has already swung onto digital stores.These include iTunes, Google Play, Vudu, Amazon, Fandango Now and Microsoft Movies & TV.You can also buy it through the Disney-owned Movies Anywhere service, and link those stores to your Movies Anywhere account to view on whichever device you want.
At its 2019 GPU Technology Conference in San Jose, graphics processor manufacturer Nvidia announced Monday that it will be releasing version 9.0 of its Nvidia Drive platform for autonomous vehicles to developers and, perhaps more interestingly, that it is also working with German standards body TÜV SÜD to develop a sort of driver's license for self-driving cars.The Nvidia Drive AP2X release 9.0 -- as the new hardware and software platform is more specifically known -- includes a few new features for autonomous vehicle developers to play with.The software will also be able to make decisions at complex intersections, work through congested traffic and automatically change into a faster moving lane without endangering the vehicle's occupants or, presumably, oncoming traffic.In areas where there is no map data for the autonomous software to use for guidance -- perhaps a private driveway or a newly paved road -- Drive 9.0 can even generate its own map data, piecing together information from cameras, lidar and radar sensors to create what Nvidia calls a Local HD map that can be used for self-driving navigation after a few human-piloted trips.Most noteworthy is Safety Force Field, a new, open-source collision avoidance algorithm for autonomous vehicles that uses computational predictions to guess where nearby cars, pedestrians and other obstructions will be in the immediate future and then act to shield autonomous vehicles from collision with a combination of emergency braking and intelligent steering around obstructions.Nvidia is making the Safety Force Field algorithm open-source for other developers to use when building their own autonomous platforms.
As smartphones get more features and better hardware, the prices rise even higher and the drain on batteries gets even bigger.Xiaomi has always prided itself for offering affordable alternatives to premium flagships but its new sub-brand pushes the price tag even lower.With the Redmi 7, Xiaomi is offering an extremely budget-friendly option that will last you throughout the day.Like its predecessors, the Redmi 7 is a mid-range phone with less than premium specs.That’s pretty much expected from a phone of its price range but that doesn’t always have to be a bad thing.For example, the Redmi 7 moves up from the Redmi 6’s MediaTek chip and carries inside a Qualcomm Snapdragon 632 instead.
Artificial intelligence and machine learning aren’t new concepts to the world of cloud computing, but Nvidia and Amazon are aiming to take it to the next level.Nvidia has announced that mainstream servers designed to run the company’s data science acceleration software are now available; additionally, Amazon will be implementing the technology into its Amazon Web Services (AWS) stack for customers looking to take advantage of accelerated machine learning tasks in the cloud.The new servers feature Nvidia’s T4 GPUs running on the company’s Turing GPU architecture; this raw hardware power combined with Nvidia’s CUDA-X A.I.libraries will enable businesses and organizations to more efficiently handle A.I.-based tasks, machine learning, data analytics, and virtual desktops.Designed for the data center the T4 GPUs draw only 70 watts of power during operation.Companies offering the new servers include Cisco, Dell EMC, Fujitsu, HP Enterprise, Inspur, Lenovo, and Sugon.