In a season of long-running shows bringing their stories to a (mostly satisfying) end, The Big Bang Theory did just that: wrap up the adventures of very smart people who live in a shared apartment and spend their free time playing Settlers of Catan.

Along with physicists Sheldon and Leonard, we also said goodbye to a character who joined in season 3 and soon moved in to the Big Bang building permanently.

Bespectacled neurobiologist Dr. Amy Farrah Fowler, alumni of Harvard and, spoiler, wife of Sheldon, represents the world of science, technology, engineering and mathematics.

Played by Mayim Bialik (of Blossom fame), Dr. Amy made her entrance as a love interest to socially inept child prodigy Sheldon Cooper, wooing him with lines like, "All forms of physical contact, up to and including coitus, are off the table."

A true TV love story rivaling Jon Snow and Ygritte soon blossomed, though with less death and more intellectual discussion.

Adept at both comedy and being really smart, Bialik is a neuroscientist in real life, having completed her Ph.D. at UCLA in 2007.

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