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The body's immune system can recognize and attack cancer cells, but when those are able to overcome this assault, malignant tumors develop in patients.

New research led by investigators at Massachusetts General Hospital (MGH) uncovers some of the key factors that are needed for survival of immune cells in the battle against cancer.

The findings, published in Cell, point to potential therapeutic targets to tip the scales so that the immune system can effectively defeat aggressive cancers.

Cytotoxic T lymphocytes (CTL) are the cells that recognize and destroy cancer cells, and they're first activated in tumor-draining lymph nodes.

"Such signals, including the cytokine IL-15, enable CTLs to survive long enough to effectively eliminate cancer cells and, under ideal conditions, reject the tumors entirely."

Mempel and his colleagues also wondered how CTLs find their way into these survival niches.