All of them have superior ergonomics, with more intuitive button layouts and a better feel than standard remotes.
My family and I have used most of the remotes below to control my main home-theater system at home for months or years at a time.
At various points they've controlled my TVs, AV receivers, game consoles, Roku streamers and a cable box DVR.
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The main appeal over cheaper, non-Harmony-based remotes, or the clicker that comes with your cable box, is the activity-based control.
Press the "Watch TV" or "Listen to Music" buttons and the remote turns on all the relevant devices (such as your TV, cable box and AV receiver), switches to the right inputs and maps the keys to that activity (Volume to the receiver and Channel up/down to the cable box, for example).