A research team Ohio State University Wexner Medical Center first decided to evaluate the possibility of any connection between the mother's immunity and the gender of the offspring.

The researchers influenced to examine this relationship, as they found some subjective evidence along with referenced scientific studies. After collecting the details from the available evidential sources, the research team found that the gender of the offspring provides impact on the mother's physiological response.

Theoretical evidence suggested that maternal blood glucose level, blood pressure, and certain hormone-like cortisol level have altered depending upon the sex of the offspring.

The human trial conducted at Ohio State University Wexner Medical Center had the aim to evaluate the factual base of the connection between the mother's immunity and the gender of the offspring.

In this study, 80 pregnant women were selected with a different gestational period. Some study participants were in first, some were in second, and some were in the third trimester.

Among them, 46 pregnant women carried male gender and 34 carried female gender offspring. Researchers had evaluated the immune response of each of the participant by exposing their immune cells to bacteria. They monitored the difference of maternal immune response depending upon their sex of the offspring.

During the evaluation, researchers examined the cytokines levels in the blood of the study participants. Cytokines are pro-inflammatory mediators which regulate inflammation and immunity response.

Body's natural immune response trigger cytokines release, when the body needs to fight against disease-causing germs. Cytokines also play an important role in cellular communication during inflammatory response occurs. But the persistent release of cytokines can also trigger certain disease conditions like fatigue, body aches.

In this research study, researchers evaluated cytokine levels in the blood and bacteria-exposed laboratory sample. The research team found that pregnant women with girl fetus produce more cytokines than women with male fetuses in bacterial exposure.

However, there is no difference in blood sample cytokines levels. In case of the immune challenging condition, pregnant women with girl fetus have a higher inflammatory response.

Pregnant women who carry female fetus tend to experience exacerbated pre-existing medical conditions due to increasing the inflammatory response in challenged immune conditions. Pregnant women who have asthma or hypersensitivity reactions carry female fetus usually experience worsen their condition.

Amanda Mitchell, the team leader of this research study also suggested that conduction of more research in this field required for a precise understanding of how pregnancy affects inflammatory response.

Excessive immune response, as well as an insufficient immune response both, can be problematic during pregnancy. Therefore, the building of balance immune functioning is very important for a pregnant woman.

Mitchell hypothesized that hormones present in the placenta during pregnancy might involve in the inflammatory response. The team leader of this research also suggested exercise, diet, general well-being, and mental and physical relaxation are very important to support healthy immune functioning during pregnancy. Dietician and physical trainer can guide the proper daily routine during pregnancy.

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This study finding open the door for further research to evaluate how immune functioning of a pregnant woman responds against different disease-causing germs like viruses, fungi attack or other infections, and even chronic health conditions like asthma and their immune responses affect the health of the fetus.

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