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Cyborg organoids offer rare view into early stages of development

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Geekz Snow
Cyborg organoids offer rare view into early stages of development

How do a small group of cells organize to become a heart, a brain, or a kidney?

This critical period of development has long remained the black box of developmental biology, in part because no sensor was small or flexible enough to observe this process without damaging the cells.

Now, researchers from the Harvard John A. Paulson School of Engineering and Applied Sciences (SEAS) have grown simplified organs known as organoids with fully integrated sensors.

These so-called cyborg organoids offer a rare glimpse into the early stages of organ development.

I think if we can develop nanoelectronics that are so flexible, stretchable, and soft that they can grow together with developing tissue through their natural development process, the embedded sensors can measure the entire activity of this developmental process," said Jia Liu, Assistant Professor of Bioengineering at SEAS and senior author of the study.

"The end result is a piece of tissue with a nanoscale device completely distributed and integrated across the entire three-dimensional volume of the tissue."

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