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3 External Factors Affecting Stability of Drugs in Capsules

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Elleder Pan
3 External Factors Affecting Stability of Drugs in Capsules

Oxygen in the atmosphere can cause oxidation of the drug contained in the capsule.

On the one hand, during the filling and fitting process, a small amount of oxygen in the atmosphere will remain in the interior of the capsule along with the air, so that some of the medicine is oxidized.

On the other hand, during the storage of the capsule, since the part is not completely sealed, the air will enter and exit the capsule as the temperature changes, so that the internal oxygen is continuously increased, making the medicine further oxidized.

Therefore, when filling the easily oxidizable drug, the air should be removed as much as possible, and the capsule should be sealed storage after the filling is completed to improve the stability of the drug.

Excessive moisture can also cause the capsule to deform.

Therefore, when filling and storing highly absorbent and unstable drugs, care should be taken to avoid contact with moisture.

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