The basis of progressive regenerative therapies is the analysis of the natural behavior of our body. Indeed, one of the main characteristics of the human body is self-defense against possible damage and the ability to "repair" any trauma (skin wounds, broken bones): thanks to the very complex system of growth factors, our body is able to do so To trigger tissue regeneration mechanisms and to heal many injuries to the body's own organs.
Platelets are cells in the body that circulate in the blood and have many functions: the most well-known is the activation of the coagulation process when bleeding occurs, but this is just one of the effects of platelets and is definitely NOT the most important, in fact platelets are among the first cells that trigger the repair process and regrowth of damaged cells (bones, skin, blood vessels, organ organs) by releasing a very high amount of growth factors.
Platelets in the blood, which are "activated" by various natural chemical factors (inflammatory processes, cytokines, macrophages, calcium ions), stimulate the cells of the damaged organ to "repair" themselves: wounds heal, bones connect, etc. If the damaged organ is repaired, the platelet stimulation is exhausted and the process stops: if the body does not send any further "help messages" (wounds, inflammations, etc.), the platelets do not intervene. Each organ is controlled by specific growth factors. ; those of the skin and hair are: IGF1, FGF, PDGF, VEGF, EGF, TX1, TGFβ.
THE PRP TREATMENT - PLASMA RICH IN PLATES IT HAPPENS IN 4 MAIN PHASES
- Blood collection with PRP tubes
- Centrifugation with special PRP centrifuge
- Separation of the centrifuged blood into 2 phases: In the lower part, red and white blood cells have settled. At the top are plasma (the liquid part of blood) and platelets and their concentrated growth factors.
- Under a sterile hood, the platelet-rich plasma is aspirated and injected by microinjections into the scalp or skin of the person from whom it was taken.
The life span of platelets is very short, which is why all necessary operations are performed in a very timely manner.
What is PRP platelet-rich plasma?
PRP is a thrombocytopenic plasma, so that the plasma obtained from the blood has a 45-fold higher platelet concentration after centrifugation. Growth factors released by platelets STIMULATE stem cells already present in the skin.
The indications of PRP in dermatology and trichology
In DERMATOLOGY AND TRICHOLOGY, PRP has also been used for several years for:
- HAIR DISEASES (androgenetic alopecia, alopecia areata, scarring alopecia).
- SKIN REJUVENATION
- AUTOIMMUNE DISEASES
- VITILIGO
- SKIN ULCERS, SURGICAL WOUNDS AND SCARS
SKIN AGE
The PRP in aesthetic dermatology
PRP is one of the most innovative and effective techniques for treating skin aging, also known as skin aging, both mild and advanced.
What does skin aging consist of?
Intrinsic aging: It is normal skin aging that, in addition to a gradual decrease in body functions, generally records aging according to time and genetic predisposition.
Extrinsic aging: Compared to normal skin aging, damage caused by external environmental influences (sun rays and lamps, environmental pollution) is aggravated. and inappropriate lifestyle habits (poor diet, smoking, insomnia).
Cell aging consists of a continuous and progressive shortening of the telomeres, the end parts of our DNA. real "erosion", which determines the inability of skin cells to repair the damage caused by the internal and external environment of our body. Evidence of this process in the skin is given by the appearance of spots and capillaries and by an increasingly pronounced sagging due to the decrease in the production of collagen and extracellular matrix, which are essential for skin tightening. In the most advanced stages of skin aging (A-Ging), pre-tumor lesions (actinic keratoses) or even tumors (basal cell or squamous cell carcinoma, melanoma) also occur.
What can be done against skin aging?
There are several medical and instrumental procedures that can decisively and effectively counteract skin aging, and only the combination of several techniques makes it possible to achieve the best results in a shorter period of time. it is able to prevent and heal the damage caused by aging, restore the ability of cells to "repair themselves" and turn the hands of our biological clock back in time. PRP is an outpatient therapy that can be combined with other injection techniques (absorbable fillers, synthetic growth factors) and physical techniques (laser, pulsed light, radio frequency).
In this process, PRP is injected deep into the scalp rather than into the scalp to stimulate the dermis and stem cells. In the Sorbellini Studio, the PRP platelet-rich plasma technique has been carried out on an outpatient basis since 2010 and treats more than 1600 patients with different stages of aging. When using the ionophoretic technique, other active ingredients can be added to the plasma, depending on the degree of aging, in order to increase the effectiveness of the PRP, such as: hyaluronic acid with a low molecular weight. Substances with calming and antioxidant effects. Biotechnological growth polypeptides.
ALOPEZIE
Platelet Rich Plasma PRP can be used in the treatment of androgenetic alopecia in men and women as it has curative effects on the hair (reduces hair loss, increases the diameter of the shaft, reduces inflammation of the scalp) and also enables PRP to be stimulated the most important and most advanced treatment for alopecia areata, especially for alopecia areata that does not respond to conventional therapies.
The regrowth rate was 60% in patients treated with PRP compared to intralesional cortisone (30%) and placebo (2%). The main indications for treatment are CHIAZZE alopecia areata and TOTAL forms of alopecia areata.
The result of regrowth in UNIVERSAL forms of alopecia areata is often significantly reduced. Effect in controlling the inflammatory process of the skin and in reducing the progression of dermal fibrosis, which is responsible for onion death. Ringalopezia is mainly used to block the progression of the disease, the ultimate destruction of the structure of the skin, the reduction of pain, burning and atrophy of the skin, but the more primitive the shape, the more it is possible to reduce the death of the stem. Cells of the onions and thus stimulate hair growth.
In very advanced forms of cicatricial alopecia, aesthetically significant hair regrowth is extremely rare. Treatment for cicatricial alopecia is generally multifocal and attempts to control the various origins of the disease.For this reason, the dermatologists at Sorbellini Studio usually establish a combination therapy not exclusively with PRP.
ADVANCED REGENERATIVE THERAPIES - PRP and Cell Therapy
Finally, a synthesized process from natural PRP, platinotrich plasma, is available in the laboratory, which has shown significant effectiveness in the treatment of androgenetic alopecia and alopecia areata for years.
After 3 years of studies, the composition of the main growth factors of PRP was reproduced with mimicked growth factors analogous to natural platelet growth factors, which made it possible to produce a gel product for hair care with very similar effectiveness Added lactorferrin, one of the most powerful anti-inflammatory agents in our body but not found in plasma.
The product is applied topically and achieves maximum penetration using the iontophoresis technique. No scalp injections are used, so it is completely painless. Side effects: A clinical study was carried out on 120 patients with androgenetic alopecia (62 women, 58 men mean 38.4 years 2014) and one in 84 patients with alopecia areata (46 men, 38 women, mean age 36.8 years 2015) with major clinical Results.
