Cytokines are a class of small molecule proteins secreted by cells that mediate and regulate immune processes, and they act in an autocrine, paracrine and endocrine manner. More than 200 types of human cytokines have been identified, which can be generally classified into interleukins, interferons, tumor necrosis factors, colony-stimulating factors, chemokines, growth factors, etc. according to their structure as well as function.
Interleukin (IL) was named after a cytokine that is secreted by white blood cells and acts among them. However, it has since been discovered that it can also be produced by and act on other cells. Nearly 40 interleukins have been identified and are given L serial numbers in the order in which they were discovered. For example, IL-2 is produced by activated T cells and can enhance the growth and proliferation of T cells themselves; IL-12 can be produced by dendritic cells, B cells, and monocytes-macrophages and can induce the directed differentiation of T cells into type 1 helper T cells.
Interferons (IFN) are named for their ability to interfere with viral infection and replication. More than 10 types of interferons have been identified and can be classified into alpha, beta and gamma (α, β and γ) types, which are subdivided into different subtypes. α and β interferons are mainly produced by virus-infected cells, while γ interferons are mainly produced by activated T cells and natural killer cells.
Tumor necrosis factor (TNF) is named after its initial discovery that it can cause hemorrhagic necrosis in tumors. There are two types of TNF: TNF-α and TNF-β. The former is mainly secreted by activated monocytes-macrophages, while the latter is mainly secreted by activated T cells.
Colony stimulating factor (CSF) is a cytokine that stimulates the proliferation and differentiation of pluripotent hematopoietic stem cells, etc., to form corresponding cell clones in semi-solid medium.
Chemokines are chemotactic cytokines that are secreted by a variety of cells.
Growth factor (GF) is a group of cytokines that promote the growth and differentiation of corresponding cells, such as nerve growth factor (NGF), vascular endothelial growth factor (VEGF), epidermal growth factor (EGF), fibroblast growth factor (FGF), transforming growth factor-β (TGF-β), etc. It has an important role in the development and differentiation of immune cells, immune response and immune regulation.
Cytokines play an important role in the development and differentiation of immune cells, immune response and immune regulation. However, it is also a "double-edged sword", which can be involved in the development of various diseases under certain conditions. For example, during the immune response, immune cells secrete large amounts of cytokines, which in turn stimulate immune cells. If this positive feedback regulation fails, a cytokine storm will result. Cytokine storms can occur in a variety of diseases, such as acute respiratory distress syndrome, SARS (severe acute respiratory syndrome), and influenza.
Creative Proteomics has extensive experience in protein identification and quantitative analysis. In order to better serve researchers in the pharmaceutical and clinical fields, Creative Proteomics has introduced Luminex technology, which can provide comprehensive cytokine analysis services to advance disease mechanism research and related pharmaceutical R&D processes.
The Global Cytokines Market Research Report – Industry Analysis, Size, Share, Growth, Trends and Forecast Till 2027 gives an evaluation of the market developments based on historical studies and comprehensive research respectively.
The market segments are also provided with an in-depth outlook of the competitive landscape and a listing of the profiled key players.The comprehensive value chain analysis of the market will assist in attaining better product differentiation, along with detailed understanding of the core competency of each activity involved.
The market attractiveness analysis provided in the report aptly measures the potential value of the market providing business strategists with the latest growth opportunities.
The report classifies the market into different segments.
These segments are studied in detail incorporating the market estimates and forecasts at regional and country level.
The segment analysis is useful in understanding the growth areas and probable opportunities of the market.Browse the complete Global Cytokines Market Research Report – Industry Analysis, Size, Share, Growth, Trends and Forecast Till 2027 @ https://www.decisiondatabases.com/ip/46868-cytokines-market-report The report also covers the complete competitive landscape of the global Cytokines market with company profiles of key players such as: AbbVieJohnson & JohnsonNovartisRochePfizerSanofiBayer HealthCare PharmaceuticalsThermo Fisher ScientificBioconGlaxoSmithKlineBiotechneThe detailed description of each has been included, with information in terms of H.Q, future capacities, key mergers & acquisitions, financial overview, partnerships, collaborations, new product launches, new product developments and other latest industrial developments.SEGMENTATIONS IN THE REPORT: By ProductTNFILIFNEGFBy ApplicationCancer and MalignancyAsthma / Airway InflammationArthritisBy Geography:North America (NA) – US, Canada, and MexicoEurope (EU) – UK, Germany, France, Italy, Russia, Spain & Rest of EuropeAsia-Pacific (APAC) – China, India, Japan, South Korea, Australia & Rest of APACLatin America (LA) – Brazil, Argentina, Peru, Chile & Rest of Latin AmericaMiddle East and Africa (MEA) – Saudi Arabia, UAE, Israel, South AfricaDownload Free Sample Report of Global Cytokines Market @ https://www.decisiondatabases.com/contact/download-sample-46868The Global Cytokines Market has been exhibited in detail in the following chapters –Chapter 1 Cytokines Market Preface Chapter 2 Executive SummaryChapter 3 Cytokines Industry AnalysisChapter 4 Cytokines Market Value Chain AnalysisChapter 5 Cytokines Market Analysis By ProductChapter 6 Cytokines Market Analysis By ApplicationChapter 7 Cytokines Market Analysis By GeographyChapter 8 Competitive Landscape Of Cytokines CompaniesChapter 9 Company Profiles Of Cytokines IndustryPurchase the complete Global Cytokines Market Research Report @ https://www.decisiondatabases.com/contact/buy-now-46868Other Reports by DecisionDatabases.com:Global Cytokines Based Therapies and Inhibitors Market Research Report – Industry Analysis, Size, Share, Growth, Trends and Forecast Till 2026About-Us:DecisionDatabases.com is a global business research reports provider, enriching decision makers and strategists with qualitative statistics.
Almost all human tissues contain MSCs, which are abundant in various tissues and organs, such as bone marrow, fat, dental pulp, umbilical cord, and placenta.
By regulating the differential expression of genes under the stimulation of specific signals and local microenvironments, they can not only differentiate into cell types derived from mesoderm, including cardiomyocytes, vascular endothelial cells, and lipid, osteogenic and chondrogenic cells can also be transdifferentiated into cells derived from endoderm such as gastrointestinal epithelial cells, lung cells, intestinal epithelial cells, muscle cells, etc., and can also be transdifferentiated into epidermal cells such as epidermal cells and nerve cells.
Activation of Wnt signaling pathway receptors on the surface of bone marrow stem cells leads to downstream signal transduction to regulate cellular processes such as proliferation and differentiation of bone marrow stem cells.
The results of animal experiments and clinical trials show that, regardless of autologous or allogeneic MSCs transplantation, only a small number of cells can colonize and survive for longtime during tissue damage repair.
MSCs acquire the anti-inflammatory phenotype MSC2, which secretes a large amount of nitric oxide (NO) and indolamine 2,3-dioxygenase (IDO) to inhibit the function of lymphocytes and weaken the immune response to reduce tissue damage caused by excessive stress.
The immune response of lymphocytes intensifies the intensity of the inflammatory response and causes tissue damage.
