BioNTech SE has taken the next step to improve vaccine supply in Africa. The company has introduced its approach to establishing scalable vaccine production by developing and delivering turnkey mRNA manufacturing facilities based on a container solution. At a high-level meeting at BioNTech's new manufacturing facility in Marburg and at the invitation of kENUP Foundation, the company presented the container solution named "BioNTainer" to its key partners.
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RNA is a hydrophilic, negatively charged macromolecule, and its ability to autonomously transmembrane is limited.
Therefore, how to efficiently deliver mRNA to the cytoplasm and play a corresponding role is one of the key issues that limit the application of RNA therapy.
An ideal delivery system can carry mRNA through the cytoplasmic membrane without being degraded by RNase, and can allow mRNA to be released into the cytoplasm for translation after entering the cell.
In recent years, a variety of strategies have been used for mRNA delivery, and most of these methods are inspired by siRNA and plasmid DNA delivery technologies.
Therefore, how to specifically deliver mRNA to target cells is currently a difficult problem.Extracellular barriermRNA molecules are very easily degraded by enzymes, so they need to be protected from RNA hydrolase (RNAse) in extracellular serum during systemic administration to ensure that mRNA can reach target cells smoothly.Inner body escapeWhen reaching the target cell, the vector carrying mRNA enters the cytoplasm through endocytosis, which is also the most common way for the vector to enter the cell.
In endosomal vesicles, mRNA can be detected by Toll-like receptors (TLRs) and sent for degradation, so endosomal escape is essential for mRNA to reach the ribosome.Intracellular immunityWhen foreign mRNA is delivered to the cytoplasm, it can be recognized by TLR3 and TLR7/8, or by activating retinoic acid-induced gene I-like receptors in the cytoplasm, thereby activating the natural immune system.
The latest trending report Global mRNA Vaccines & Therapeutics Market 2020 by Manufacturers, Regions, Type and Application, Forecast to 2025 offered by DecisionDatabases.com is an informative study covering the market with detailed analysis.
The report will assist reader with better understanding and decision making.The mRNA Vaccines & Therapeutics market report provides a detailed analysis of global market size, regional and country-level market size, segmentation market growth, market share, competitive Landscape, sales analysis, impact of domestic and global market players, value chain optimization, trade regulations, recent developments, opportunities analysis, strategic market growth analysis, product launches, area marketplace expanding, and technological innovations.This report also researches and evaluates the impact of Covid-19 outbreak on the mRNA Vaccines & Therapeutics industry, involving potential opportunity and challenges, drivers and risks.
We present the impact assessment of Covid-19 effects on mRNA Vaccines & Therapeutics and market growth forecast based on different scenario (optimistic, pessimistic, very optimistic, most likely etc.
).Final Report will cover the impact of COVID-19 on this industry.Browse the complete report and table of contents @ https://www.decisiondatabases.com/ip/29833-mrna-vaccines-and-therapeutics-market-analysis-reportThe major players covered in mRNA Vaccines & Therapeutics are:Moderna TherapeuticseTheRNABioNTechCureVacIn-Cell-ArtTranslate BioTiba BiotechnologyArgos TherapeuticsSangamo TherapeuticsEthrisBy Type, mRNA Vaccines & Therapeutics market has been segmented intoStandardization Of Cancer Treatment MRNA VaccineIndividualized Cancer Treatment MRNA VaccineInfectious Disease Treatment MRNA VaccineInfection Prevention MRNA VaccineBy Application, mRNA Vaccines & Therapeutics has been segmented into:Infectious DiseaseCancerOtherThe report offers in-depth assessment of the growth and other aspects of the mRNA Vaccines & Therapeutics market in important countries (regions), including:North America (United States, Canada and Mexico)Europe (Germany, France, UK, Russia and Italy)Asia-Pacific (China, Japan, Korea, India and Southeast Asia)South America (Brazil, Argentina, etc.
)Middle East & Africa (Saudi Arabia, Egypt, Nigeria and South Africa)Download Free Sample Report of Global mRNA Vaccines & Therapeutics Market @ https://www.decisiondatabases.com/contact/download-sample-29833The content of the study subjects, includes a total of 15 chapters:Chapter 1, to describe mRNA Vaccines & Therapeutics product scope, market overview, market opportunities, market driving force and market risks.Chapter 2, to profile the top manufacturers of mRNA Vaccines & Therapeutics, with price, sales, revenue and global market share of mRNA Vaccines & Therapeutics in 2018 and 2019.Chapter 3, the mRNA Vaccines & Therapeutics competitive situation, sales, revenue and global market share of top manufacturers are analyzed emphatically by landscape contrast.Chapter 4, the mRNA Vaccines & Therapeutics breakdown data are shown at the regional level, to show the sales, revenue and growth by regions, from 2015 to 2020.Chapter 5, 6, 7, 8 and 9, to break the sales data at the country level, with sales, revenue and market share for key countries in the world, from 2015 to 2020.Chapter 10 and 11, to segment the sales by type and application, with sales market share and growth rate by type, application, from 2015 to 2020.Chapter 12, mRNA Vaccines & Therapeutics market forecast, by regions, type and application, with sales and revenue, from 2020 to 2025.Chapter 13, 14 and 15, to describe mRNA Vaccines & Therapeutics sales channel, distributors, customers, research findings and conclusion, appendix and data source.Purchase the complete Global mRNA Vaccines & Therapeutics Market Research Report @ https://www.decisiondatabases.com/contact/buy-now-29833All Vaccine Related Reports by DecisionDatabases.com @ https://goo.gl/Q2GmDtAll Therapeutics Related Reports by DecisionDatabases.com @ https://goo.gl/pzpPL3About-Us:DecisionDatabases.com is a global business research reports provider, enriching decision makers and strategists with qualitative statistics.
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