For the objectives of magnetoreception, hyperthermia, and Magnetic Driven Drug Delivery Technology, magnetic nanoparticles have become increasingly important. We have outlined important experimental strategies together with their benefits and drawbacks with regard to potential clinical translation. This field is active and promises to make significant contributions to the creation of cutting-edge cancer treatments.
Due to their small dimensions (100 nm), magnetic nanoparticles can efficiently extravasate and target sick regions like infected tissue (lesions) or tumor tissue. In mouse models, the extravasation process has been established. Compared to rodents, humans have substantially lower levels of increased permeation and retention (EPR). There is a large difference in EPR between different tumor kinds and certain patients. The duration of cancer treatment with nanoformulations affects the strength of EPR as well. The primary application of magnetic forces is to facilitate targeted medicine delivery.
Time-variant magnetic fields have been utilized to cause drug release from thermally sensitive nanocarriers, while spatially variant magnetic fields have been employed to promote the formation of medication-loaded magnetic nanoparticles at target regions. To cause drug release from thermally susceptible nanocarriers or to improve the accumulation of drugs at an intended location via Magnetic Driven Drug Delivery Technology, magnetic fields can be utilised in conjunction with magnetised nanoparticles.
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