Treatment options include waiting it out, total surgical removal, radiation therapy, chemotherapy, antiestrogens SAIDs, or ablation (cold, heat, or ultrasound). The success rates of treatment with oral tyrosine kinase inhibitors, such as imatinib, sorafenib, and pazopanib, are encouraging. A multidisciplinary team composed of surgeons, medical oncologists, radiation oncologists, and geneticists should assess patients with desmoid tumors. Desmoid Tumors cannot be cured, hence patients are advised to participate in clinical studies whenever practical. The only reliable way to identify the type of tumor is to perform a biopsy. The fundamental issue with the management of these lesions is the high rates of recurrence in FAP-associated disease.
Contrarily, although significant surgery may still be necessary for local symptoms in intra-abdominal fibromatosis without evidence of FAP, the chance of recurrence appears to be decreased. The most popular procedure is a large surgical resection with clear margins, with hormonal therapy, chemotherapy, or radiation therapy being utilized to lower the likelihood of recurrence. Patients with difficult desmoid tumors, such as those involving the mesenteric root, or those who have intestinal insufficiency as a result of the tumor or previous procedures may benefit from an intestine transplant. Desmoid Tumors have traditionally been treated with surgery, however this may be changing. After surgery, the tumor frequently returns to the same spot, therefore doctors are seeking for alternative therapies. Additionally, radiation therapy is a possibility for treating some desmoid tumors.
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