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A New Approach to Smart Insulin

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Gregory Santulli
The higher the glucose level, the more the connections between the building blocks fail—and the more insulin is released through leaks between the blocks. What I’ve just described, in layman’s terms, is the chemist John Fossey’s idea for how to deploy glucose responsive insulin, or GRI. Fossey runs a research group at the University of Birmingham in England, where he applies chemistry to try to solve real-world problems. 
 
Until recently, he knew little about the field of diabetes research. But through an email list, he caught wind of a request for applications put out by JDRF, looking for researchers outside the field who could bring new approaches to developing a GRI. To learn more about the project, he logged into a Webinar run by Dr. Sanjoy Dutta. 
As Fossey listened to the Webinar, he realized that his lab’s expertise in creating molecules of various shapes could be a good match. “I was listening to the presentation and I thought, This is us! We have this! I didn’t know about this need before.”
 
“It is our firm conviction that if we don’t continue to lead this area, this area will perish. I look at JDRF as oxygen in this field.” And part of that oxygen is bringing in knowledge from new corners of the science world. “We need some diabetes research expertise to help us reach our dream. John has a unique battery of expertise that we conventionally don’t work with—chemically activatable GRI.

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Gregory Santulli
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