He will claim that the Government appears to have “lost control” and there were signs that MPs were prepared to take action to “assert the authority” of Parliament.

Highlighting a generational split in the result of the 2016 referendum, he will say “those of a certain age who voted 70:30 to leave” are “rapidly being replaced by a younger generation who voted 70:30 to stay”.

At the rally in London’s ExCel centre, which will also be addressed by politicians including Liberal Democrat leader Sir Vince Cable, Tory former ministers Anna Soubry and Philip Lee and celebrities including Charles Dance and Jason Isaacs, Lord Heseltine will claim that those campaigning for a second vote are “British patriots” who are “proud of our Commonwealth and empire”.

The event, organised by the Best for Britain and People’s Vote campaigns, will feature politicians from the Tories, Labour, Liberal Democrats, Green Party and Plaid Cymru.

Heseltine will hit out at Brexiteers who have called pro-EU politicians “traitors”, saying: “May our opponents never be forgiven for their allegations that it is us who are letting Britain down.”

He will say: “Let us make our position clear.

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