Monoamine oxidase (MAO) inhibitors are potential drug candidates for treating neurological disorders such as anxiety, Alzheimer's disease and Parkinson's disease.
This review presents information about MAO inhibitory effects of the umbelliferone based derivatives.
The potential antioxidant effects of the derivatives were evaluated by DPPH and H2O2 scavenging methods.
The derivatives were screened for hMAO-A and hMAO-B inhibition through a series of different umbelliferone derivatives was designed and synthesized for experimental conditions.
Through docking simulation, the mechanistic insight for enzyme- compound infractions was achieved.
By two spectrophotometric titration methods, the antioxidant potential was dually assessed.