First there was one, now there are two: A second cancer patient has been treated with a bone marrow transplant, and it looks like that treatment cured him of AIDS.This is the second time scientists have done this — the first person cured of AIDS was an American man named Timothy Brown (originally nicknamed "the Berlin patient").Brown received a bone marrow transplant in 2007 to help treat his aggressive leukemia."It's cool because before this we had an 'n' of one," microbiologist Jeffrey Milush, who directs the UCSF Core Immunology Laboratory, told Business Insider.The scientists behind the feat are still approaching the case cautiously, though.In both cases, the patients weren't specifically trying to cure their HIV; they were dealing with aggressive strains of cancer, and their oncologists recommended bone marrow transplants to treat it.
I know it’s everyone’s dream to see outside the wavelengths allotted to our visual systems.Well, as usual, mice have gotten there first, with the help of some clever scientists.By injecting specialized light-tweaking nanoparticles into a mouse’s retina, that mouse is suddenly and clearly able to perceive near-infrared light — suggesting the same could be possible for us, assuming you don’t mind a needle in the eye.The human eye can only see wavelengths of light between about 430 and 770 nanometers; above that is ultraviolet and below it is infrared.All objects give off IR, increasingly so the warmer they are, which is the basis for heat vision goggles.We do it all the time, of course — convert one kind of light or energy into another.
Every person in the U.S. will experience, on average, two broken bones in their lifetime.Average recovery time for a young, healthy adult with a broken arm is six to eight weeks.Recovery can take six months to a year.One out of three will die due to complications within one year, and for those surviving only 50 percent will regain full mobility within a year, the NIH reports.Costs of treating fractured hips continues to skyrocket.A new injectable bone healing drug could change the treatment of breaks, fractures and weak bones.
Insulin pills have long been a kind of Holy Grail for people living with diabetes.A research team at MIT believes it may have taken an important step toward that dream with a new blueberry-sized capsule made of compressed insulin.Once ingested, water dissolves a disk of sugar, using a spring to release a tiny needle made up almost entirely of freeze-dried insulin.The needle is injected into the stomach — which the patient can’t feel, owing to a lack of pain receptors in the stomach.Once the injection has occurred, the needle can break down in the digestive tract.The pill is able to orient itself once swallowed, in order to make sure it injects in the right spot.
While the zombies and monstrosities that walk amongst Resident Evil’s protagonists are usually visually unsettling, the audio is what takes the terror to the next level.Resident Evil 2, both the PS1 original and the 2019 remake, are prime examples of Capcom’s sound design prowess for horror games.I spoke with Resident Evil 2 audio director Kentaro Nakashima about the process of creating sounds for the remake.From the different reload sounds to footsteps to the creepy noises in the darkness, a sizable portion of the atmosphere and terror came from what you heard.This challenge greatly motivated the entire sound team and influenced every aspect of the design, helping us to uncompromisingly produce sounds of horror that I believe no one’s heard before.However, for the remake, we decided to actually record the reverb we needed for every room and hallway in every stage, thus creating our own IRs.
Alex Stamos, Facebook’s former chief security officer, who left the company this summer to take up a role in academia, has made a contribution to what’s sometimes couched as a debate about how to monetize (and thus sustain) commercial end-to-end encrypted messaging platforms in order that the privacy benefits they otherwise offer can be as widely spread as possible.Stamos made the comments via Twitter, where he said he was indirectly responding to the fallout from a Forbes interview with WhatsApp co-founder Brian Acton — in which Acton hit at out at his former employer for being greedy in its approach to generating revenue off of the famously anti-ads messaging platform.And while Stamos has avoided making critical remarks about Acton (unlike some current Facebook staffers), he clearly wants to lend his weight to the notion that some kind of trade-off is necessary in order for end-to-end encryption to be commercially viable (and thus for the greater good (of messaging privacy) to prevail); and therefore his tacit support to Facebook and its approach to making money off of a robustly encrypted platform.Stamos’ own departure from the fb mothership was hardly under such acrimonious terms as Acton, though he has had his own disagreements with the leadership team — as set out in a memo he sent earlier this year that was obtained by BuzzFeed.This approach means Facebook can carry out its ad targeting activities across both messaging platforms (as it will from next year).It is also, at least in Stamos’ view, a trade off that’s worth it for the ‘greater good’ of message content remaining strongly encrypted and therefore unreadable.
US telecoms regulator the FCC is set to provide a substantial cash injection over the next ten years to expand rural broadband availability.Over the next decade, some 713,176 homes and businesses across 45 states will benefit from the investment.The FCC is seeking minimum broadband speeds of 100Mbps in 53 percent of the rural locations targeted.Over 99.7 percent of these locations will receive at least 25 Mbps downstream speeds.Better still, according to the FCC, 19 percent of locations will get access to gigabit services.There were 103 winning bidders in the auction, with the 10-year support amount totalling $1.488 billion.
Is the world in need of yet another pair of wireless sports headphones?When we woke up this morning, we’d have answered no.But after spending some time with Bang & Olufsen’s new $300 Beoplay E6 headphones at the IFA consumer electronics show in Berlin this morning, we think there’s room for another premium option — and these would be our pick.Bang & Olufsen’s design and style flair are hard to represent in something as simple as wireless headphones; the company’s unique vision shines in larger products, such as the freshly announced Beosound Edge, a wireless speaker that’s essentially an upscaled version of the old British Pound coin.But when you hold the E6 in your hand, you feel what separates them from the crowd.Aside from offering the kind of refined, high-end sound quality that is woefully lacking in most sports-oriented headphones, Bang & Olufsen has infused the Beoplay E6 with premium materials.
If you were at Disrupt London four years ago you may remember more than a little awkwardness during an investor panel when two VCs that had invested in European payday loans firm Wonga declined to comment on what had gone wrong at their portfolio company in the wake of a £220M write down.Yesterday Sky News reported that those same two, Accel Partners and Balderton Capital, are among a group of Wonga investors that have agreed to inject a further £10M (~$13M) into the business to help fund compensation claims related to its past censured practices.By 2014 rising concern about the rates of interest being charged to vulnerable customers on short term loan products led to a regulatory intervention to clean up the sector, and Wonga agreed to write off the loans of 330,000 customers.It also agreed to waive the interest and fees for a further 45,000 after admitting its automated checks had failed to adequately assess affordability.The algorithmic technology it had touted as its core IP had been lending money to people who did not have the income to pay it back.The company was also censured by the Financial Conduct Authority (FCA) for sending fake lawyers’ letters to customers in arrears — and had to pay out a further £2.6M in compensation for that.
There’s a layer of living creatures covering each of our bodies, inside and out, from the tips of our fingers to the linings of our intestines.These microbes — many of them good, some of them bad, most of them benign — help us digest food, fend of disease, and contribute to our unique stench when we sweat.Some promising studies have shown that certain microbes in the gut can have an effect on mental health, making people more or less anxious.So what if scientists could design an injection packed with beneficial microbes aimed at treating mental health disorders?That’s the question that came to mind for Matt Frank, a psychology and neuroscience researcher at the University of Colorado, Boulder, after he and his colleagues injected rodents with probiotics in a recent study.In a paper published this week in the journal Brain, Behavior and Immunity, Frank and his team show that a particular bacterium can encourage a rodent’s brain into a state that resists inflammation, potentially paving the way for probiotic immunizations to treat stress-related mental disorders like PSTD and anxiety.
AIBP binds to toll-like receptor 4 (TLR4), a protein that sits on the surface of cells like an antenna, searching for signs of infection or tissue damage.As reported May 29 by Cell Reports, the treatment alleviated chemotherapy pain in mice for two months with no side effects."At the same time, opioids also impart a feeling of pleasure, which leads to their misuse and addiction.We're blocking the underlying mechanism that causes pain, not just masking the symptoms."But a few years ago, he, co-author Maripat Corr, MD, and collaborators found that sometimes inflammation can transition to chronic pain with all the hallmarks of nerve injury -- a cellular event that involves TLR4.But we were also surprised to find that at the same time AIBP prevented and reversed chronic pain states.
Sometimes two companies get along so well together and fit each other so perfectly, they almost have to come together.That’s what happened when Dialpad, a business communications platform whose products include UberConference, started working with TalkIQ.Dialpad CEO Craig Walker says the two companies actually started working together about 8 months ago when Dialpad began looking at artificial intelligence options and they found that most weren’t real time and were expensive.Walker liked the fact that TalkIQ had that near real-time solution and that it was also built on the Google Cloud Platform like his company.In addition, the principals from both companies each came out of Google and had actually worked together at various points.When the teams came together under that commercial agreement, Walker says, they really clicked.
A team of neuroscientists at UCLA yesterday unveiled the results of an experiment involving snail brains that could radically change our understanding of how memories work.That is, if the rest of the scientific community can suspend its disbelief long enough to give the group’s ideas serious consideration.The scientists, led by Dr. David Glanzman, extracted RNA from the brains of Aplysia – sea slugs – and then injected it into the brain of another Aplysia.Moreover, a specific cellular alteration that underlies sensitization in Aplysia, sensory neuron hyperexcitability, can be reproduced by exposing sensory neurons in vitro to RNA from trained animals.This, however, stands in opposition to longstanding notions of how brains form memories — through the formation of strong synaptic connections between neurons.It all started in the 60s when an eccentric professor at the University of Michigan, Dr. James V. McConnell, started grinding up tapeworms and feeding them to other tapeworms.
Researchers at the University of California San Diego have developed a tiny ultra-low power biosensor that’s designed to be injected into the body for continuous alcohol monitoring.Unlike the wearable alcohol monitors we’ve previously covered at Digital Trends, which let drinkers know if they’re over the legal alcohol limit on individual nights out, the UC San Diego device is intended to be used for long-term monitoring of patients in substance abuse treatment programs.It can be injected under the skin in interstitial fluid, the fluid which surrounds the body’s cells.The first is coated with alcohol oxidase, an enzyme that reacts with alcohol to generate a byproduct which can be detected electrochemically.The second measures background signals, while the third detects pH levels.These last two levels are then canceled out to make the alcohol reading more accurate.
A penetrating injury from shrapnel is a serious obstacle in overcoming battlefield wounds that can ultimately lead to death.Given the high mortality rates due to hemorrhaging, there is an unmet need to quickly self-administer materials that prevent fatality due to excessive blood loss.With a gelling agent commonly used in preparing pastries, researchers from the Inspired Nanomaterials and Tissue Engineering Laboratory have successfully fabricated an injectable bandage to stop bleeding and promote wound healing.In a recent article "Nanoengineered Injectable Hydrogels for Wound Healing Application" published in Acta Biomaterialia, Dr. Akhilesh K. Gaharwar, assistant professor in the Department of Biomedical Engineering at Texas A University, uses kappa-carrageenan and nanosilicates to form injectable hydrogels to promote hemostasis (the process to stop bleeding) and facilitate wound healing via a controlled release of therapeutics."Injectable hydrogels are promising materials for achieving hemostasis in case of internal injuries and bleeding, as these biomaterials can be introduced into a wound site using minimally invasive approaches," said Gaharwar."An ideal injectable bandage should solidify after injection in the wound area and promote a natural clotting cascade.The study uses a commonly used thickening agent known as kappa-carrageenan, obtained from seaweed, to design injectable hydrogels.
Making its official debut at the Geneva Motor Show 2018 next week, the new A6 brings the German automaker’s full-size sedan into its eighth generation, borrowing gadgetry from the larger and more expensive 2019 Audi A8.That doesn’t just help with economy, but how much road noise makes it through to the cabin, too.It’s also more spacious inside, with more head, leg, and shoulder room in the rear, and a broader trunk that can now handle two golf bags horizontally, even though its 18.7 cu-ft capacity is unchanged.Despite all that, Audi promises a more engaging drive versus the old A6.Standard progressive steering tightens up as the steering angle increases, while there’s dynamic all-wheel steering too that allows both the front and rear wheels to turn.At low speeds, the rear wheels turn in the opposite direction to the front, tightening up the turning circle; at high speeds, meanwhile, they turn in the same direction, optimizing stability during lane-change maneuverers.
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Because they can be programmed to travel the body and selectively target cancer and other sites of disease, nanometer-scale vehicles called nanocarriers can deliver higher concentrations of drugs to bombard specific areas of the body while minimizing systemic side effects.Nanocarriers can also deliver drugs and diagnostic agents that are typically not soluble in water or blood as well as significantly decrease the effective dosage."Controlled, sustained delivery is advantageous for treating many chronic disorders, but this is difficult to achieve with nanomaterials without inducing undesirable local inflammation," said Northwestern University's Evan Scott.Now Scott, an assistant professor of biomedical engineering in Northwestern's McCormick School of Engineering, has developed a new mechanism that makes that controlled, sustained delivery possible.Scott's team designed a nanocarrier formulation that -- after quickly forming into a gel inside the body at the site of injection -- can continuously release nanoscale drug-loaded vehicles for months.The gel itself re-assembles into the nanocarriers, so after all of the drug has been delivered, no residual material is left to induce inflammation or fibrous tissue formation.