Intradermal antigen (IgE) neutralization assays can measure the amount of neutralizing antibodies in the blood, and they provide information about the type of antigens recognized by the immune system.Intradermal antibody immunity is a passive protective mechanism where antibodies or plasma cells from the peripheral immune system are detected and bind to antigens present on the surface of virus particles.

However, some viruses cause immune suppression and the absence of antigens may not cause the same reaction.

Intradermal antibody (IA) neutralization tests are used to determine if a patient has a positive response to a vaccination or if they have been vaccinated but are unresponsive to the vaccine.Interferon Neutralization TestInterferon neutralization tests measure antibody responses to interferons.

Interferons are proteins produced by the interferon regulatory factor and they have the ability to attach to the receptor of the target cells.

When interferon binds to a receptor, it activates an effector molecule, which in turn causes T-cells to produce antibodies to attack the invader.

The exact measurement of the IAA neutralization test requires several factors including antigen type, concentration of intracellular antibodies, and duration of infection.Monoclonal Antibody Test (MAb)Another test for the measurement of IgE immunity against infection is the monoclonal antibody test (MAb).