The researchers influenced to examine this relationship, as they found some subjective evidence along with referenced scientific studies. After collecting the details from the available evidential sources, the research team found that the gender of the offspring provides impact on the mother's physiological response. The human trial conducted at Ohio State University Wexner Medical Center had the aim to evaluate the factual base of the connection between the mother's immunity and the gender of the offspring. Cytokines are pro-inflammatory mediators which regulate inflammation and immunity response. The research team found that pregnant women with girl fetus produce more cytokines than women with male fetuses in bacterial exposure. Pregnant women who carry female fetus tend to experience exacerbated pre-existing medical conditions due to increasing the inflammatory response in challenged immune conditions.