BRAF is a kinase enzyme that helps control cell growth and signaling. It may be found in a mutated (changed) form in some types of cancer, including melanoma and colorectal cancer. Blocking mutated BRAF kinase proteins helps to stop the cancer cells from growing. Some BRAF kinase inhibitors are used to treat cancer. Product approvals by regulatory bodies in various regions across the globe are expected to drive growth of the market during the forecast period. For instance, in July 2020, Roche announced that the U.S. Food and Drug Administration approved Tecentriq (atezolizumab) plus Cotellic (cobimetinib) and Zelboraf (vemurafenib) for the treatment of BRAF V600 mutation-positive advanced melanoma patients.
BRAF Kinase Inhibitors Market – Impact of Coronavirus (Covid-19) Pandemic
As the novel coronavirus has spread across the globe, it has created profound disruption across communities, hospitals, and other healthcare settings, and the way it works. Product development has experienced disruption, as researchers have to adjust to remote work environments and lab capacity is reduced. Clinical trials are also being severely affected with disruptions in both new enrollment and in keeping existing patients on therapies. According to the clinicaltrial.gov, as of April 2020, there were more than 2,850 trials and approximately 900,000 patients enrolled at trial sites in regions that were in partial or complete lockdown due to COVID-19 restrictions. The R&D labs are operating at below 50% of normal capacity.
The BRAF kinase inhibitors market is estimated to be valued at US$ 924.8 million in 2020 and is expected to exhibit a CAGR of 8.6% during the forecast period (2020-2027).
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The robust pipeline for treatment of metastatic cancers and increasing prevalence of cancer are expected to boost growth of the BRAF kinase inhibitors market
Several companies have ongoing clinical trials of BRAF kinase inhibitors drugs. The robust pipeline of BRAF kinase inhibitor drugs is expected to significantly drive growth of the global BRAF kinase inhibitors market in the near future. For instance, in June 2020, BeiGene, Ltd., a commercial-stage biotechnology company and SpringWorks Therapeutics, Inc., a clinical-stage biopharmaceutical company, announced the presentation of preclinical data and provided a program update on their ongoing Phase 1b/2 study evaluating the combination of BeiGene’s investigational RAF dimer inhibitor, lifirafenib, with SpringWorks’ investigational MEK inhibitor, mirdametinib, in patients with advanced or refractory solid tumors harboring mutations in the MAPK pathway, including those with RAS mutations.
Furthermore, BRAF kinase inhibitors market is expected to witness high growth over the forecast period, owing to increasing incidence and prevalence of metastatic cancer. For instance, according to the Centers for Disease Control and Prevention provided data for 2012 to 2016, around 77,698 new cases of melanoma cancer (45,854 among men and 31,845 among women) were diagnosed every year in the U.S. Moreover, the American Cancer Society estimated that around 100,350 new cases of melanoma will be diagnosed and around 6,850 deaths are estimated to occur due to melanoma in the U.S. in 2020. Hence, such drivers are expected to positively impact the global BRAF kinase inhibitors market growth.
BRAF Kinase Inhibitors Market – Restraints
Medications and surgical operations are used to prevent or slow down further damage from occurring. Extensive R&D activities and manufacturing makes the drugs very expensive, which is expected to hamper the BRAF kinase inhibitors market growth over the forecast period. For instance, according to data published in National Center for Biotechnology Information (NCBI), by Experimental Hematology & Oncology, by year 7 of metastatic cancer, the cumulative costs per month were US$ 4,281 for ipilimumab, compared to US$ 8,920 for dabrafenib, US$ 10,211 for trametinib, US$ 11,002 for vemurafenib, and US$ 19,132 for dabrafenib + trametinib combination therapy.
BRAF Kinase Inhibitors Market – Regional Analysis
North America is estimated to hold the dominant position in 2020 in the global BRAF kinase inhibitors market. Increasing number of product approvals by the regulatory authorities is a major factor that propels growth of the North America BRAF kinase inhibitors market. For instance, in July 2020, the U.S. Food and Drug Administration (FDA) approved the PD-L1 inhibitor atezolizumab (Tecentriq) plus the MEK inhibitor cobimetinib (Cotellic) and the selective BRAF kinase inhibitor vemurafenib (Zelboraf) for the treatment of patients with advanced BRAF V600 mutation–positive melanoma. The approval is based on results from IMspire150, a multicenter, double-blind, placebo-controlled randomized phase III study.
Moreover, Europe BRAF kinase inhibitors market is also expected to gain momentum over the forecast period. For instance, in September 2018, Pierre Fabre announced that the European Commission (EC) granted marketing authorization for the combination of BRAFTOVI (encorafenib) and MEKTOVI (binimetinib) for the treatment of adult patients with unresectable or metastatic melanoma with a BRAFV600 mutation, as detected by a validated test. The EC decision is applicable to all 28 European Union (EU) member states and Liechtenstein, Iceland, and Norway.
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BRAF Kinase Inhibitors Market - Competitive Landscape
Key players operating in the global BRAF kinase inhibitors market include F. Hoffmann-La Roche AG, Novartis International AG, and Pfizer, Inc.
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Kids’ Smartwatch MarketThe kids’ smartwatch market spans across North America, Europe, Asia-Pacific Middle East & Africa, and Central and South AmericaFREE PDFhttps://www.marketresearchfuture.com/sample_request/8309@ Smartwatch is a portable wearable computing device that closely resembles a wristwatch.
Some smartwatches also consist of features such as a small and unobtrusive (SOS) button that alerts the parents if the child is in distress and a geofencing function that sends an alert whenever the child enters or leaves a designated area.The geographic analysis of the kids’ smartwatch market has been conducted for North America, Europe, Asia-Pacific (APAC), the Middle East and Africa, and Central and South America.
Asia-Pacific accounted for the largest market share in 2018, with a market value of USD 147.0 million; the market is expected to register a significant CAGR during the forecast period.
The significant gadget consuming culture of China, availability of local brands providing affordable products, fast adoption of new technologies, and increasing middle-class population with high disposable income are some of the factors influencing the demand for kids’ smartwatches.
One such instance is the product recall of kids’ smartwatch named Enox Safe-Kid-One as it was discovered that the smartwatch could easily be hacked by third parties, thus allowing strangers to keep track of children.
According to Centers for Disease Control and Prevention (CDC), the prevalence of obesity among children and adolescents aged 2–19 years was 18.5% affecting 13.7 million kids and adolescents in 2018 in the US.
Market InsightsAccording to the reports published by Market Research Future, the global lab-on-a-chip device market is projected to exhibit robust growth with registering a CAGR of 10% by the year 2023.
The lab-on-a-chip device brings diverse laboratory processes on a minimally sized integrated circuit and thus, eases the sample handling process and delivers results with excellent efficiency.Latest Free Sample Copy Available @ https://www.marketresearchfuture.com/sample_request/6215With that, quick sampling with precise results within a short span of time can easily solve problems such as drug wastage as well as drug resistance.
Therefore, lab-on-a-chip offers optimization of the process and gains traction in various corners of the pharmaceutical sector.
Similarly, other factors such as multiple advantages of microfluidic technology, rise in demand for diagnostics, expanding global population with the prediction of significant growth opportunities, and technological advancements in laboratories have amplified the penetration and growth of the lab-on-chips market globally.
By the mode of technology, the market is segmented into microarrays, microfluidics, tissue biochip, and others.By the mode of the application, the market is segmented into genomics, proteomics, the point of care diagnostics, drug discovery, and others.Lastly, accounting on the end-user, the market is segmented as hospitals and clinics, biotechnology and pharmaceutical companies, forensic laboratories, diagnostics centers, and academic & research institutes.Regional OutlookOn a geographical note, the global lab-on-a-chip device market has covered the main regions of America, Europe, Asia Pacific, and the Middle East & Africa.Among all, the Americas is the market leader and has an attractive lab-on-a-chip devices market growth owing to mounting advances in molecular biology and genetic engineering techniques as well as increasing prevalence of infectious diseases.
According to stats by the Centers for Disease Control and Prevention report in the year 2017, around 49.9% of the children between the ages of 6 months to 17 years received an influenza vaccine.
The rise in the market can be attributed due to home market growth in healthcare and benefits of using traditional prefilled syringes.Europe Prefilled Syringes Market By Material (Glass Prefilled Syringes, Polymer Based Prefilled Syringes, Plastic Prefilled Syringes), Design (Single-Chamber Prefilled Syringes, Customized Prefilled Syringes, Dual-Chamber Prefilled Syringes), Type (Conventional Prefilled Syringe, Safety Prefilled Syringes) Therapeutics (Large Molecules, Small Molecules), Application (Monoclonal Antibodies, Rheumatoid Arthritis, Anaphylaxis, Cancer, Diabetes, Multiple Sclerosis, Vaccines and Others), Distribution Channel (Hospitals, Mail Order Pharmacies, Ambulatory Surgery Centers), Country (Germany, Italy, U.K., France, Spain, Netherlands, Belgium, Switzerland, Turkey, Russia, Rest of Europe) - Industry Trends and Forecast to 2026Get Sample Report@ https://www.databridgemarketresearch.com/request-a-sample/?dbmr=europe-prefilled-syringes-marketMarket Definition: Europe Prefilled Syringes MarketA pre-filled syringe is a disposable syringe that is supplied with the substance to be injected.
Over the duration of 2017, an estimated 72,000 drug overdose fatalities have been recorded to mark a rise of about 10% in 2017, nearly half of which could have been avoided by the use of pre-filled syringes in healthcare procedures according to the Center for Disease Control.Market Drivers· Home market growth in healthcare is driving the growth of the market· Increased use of injectable medicines is propelling the growth of the market· Enhanced chronic disease occurrence is boosting the growth of the market· Benefits of using traditional prefilled syringes is contributing to the growth of the marketMarket Restraints· Strong federal rules is hampering the growth of the market· Different drug delivery methods are available which is hindering the growth of the market· Remembrance of material is restricting the growth of the marketGet Detailed Report@ https://www.databridgemarketresearch.com/reports/europe-prefilled-syringes-marketCompetitive Analysis:Europe prefilled syringes market is highly fragmented and the major players have used various strategies such as new product launches, expansions, agreements, joint ventures, partnerships, acquisitions, and others to increase their footprints in this market.
The report includes market shares of prefilled syringes market for Europe.Key Market Competitors:Few of the major market competitors currently working in the Europe prefilled syringes market are BD, Stevanato Group, WIPO, Vetter Pharma,, CHEMI S.p.A., NIPRO, Daetwyler Holding, Bayer AG, SCHOTT AG, Gerresheimer AG, Haselmeier, Catalent, Inc, Baxter, Medtronic, West Pharmaceutical Services, Inc.,Terumo Corporation among others.Get Access Report @ https://www.databridgemarketresearch.com/checkout/buy/singleuser/europe-prefilled-syringes-marketResearch Methodology: Europe Prefilled Syringes MarketData collection and base year analysis is done using data collection modules with large sample sizes.
To know more about the research methodology, drop in an inquiry to speak to our industry experts.Primary RespondentsDemand Side: Doctors, Surgeons, Medical Consultants, Nurses, Hospital Buyers, Group Purchasing Organizations, Associations, Insurers, Medical Payers, Healthcare Authorities, Universities, Technological Writers, Scientists, Promoters, and Investors among othersSupply Side: Product Managers, Marketing Managers, C-Level Executives, Distributors, Market Intelligence, and Regulatory Affairs Managers among others.Request for Detailed TOC @ https://www.databridgemarketresearch.com/toc/?dbmr=europe-prefilled-syringes-marketKey Developments in the Market:In May 2019, Fresenius Kabi AG, maker of the EU-authorized biosimilar adalimumab, Idacio, has introduced its drug in Germany.
Fresenius Kabi also made the biosimilar eligible for purchase in pre-filled syringes, pre-filled pens and vial presentations.
Data source included pharmacokinetic, biosimilar and immunogenic safety trials in healthy volunteers and phase 3 moderate and extreme Psoriasis clinicians of up to 52 weeks of reported results.
Kids Smartwatch Market ShareThe kids’ smartwatch market spans across North America, Europe, Asia-Pacific Middle East & Africa, and Central and South AmericaSmartwatch is a portable wearable computing device that closely resembles a wristwatch.
The smartwatches for kids are becoming popular as these devices are equipped with features that favor a child’s development along with various entertainment and educational features.
Also, through in-built GPS-tracker in these smartwatches, parents can stay connected to their children with ease.
Some smartwatches also consist of features such as a small and unobtrusive (SOS) button that alerts the parents if the child is in distress and a geofencing function that sends an alert whenever the child enters or leaves a designated area.The geographic analysis of the kids’ smartwatch market has been conducted for North America, Europe, Asia-Pacific (APAC), the Middle East and Africa, and Central and South America.
Asia-Pacific accounted for the largest market share in 2018, with a market value of USD 147.0 million; the market is expected to register a significant CAGR during the forecast period.
The significant gadget consuming culture of China, availability of local brands providing affordable products, fast adoption of new technologies, and increasing middle-class population with high disposable income are some of the factors influencing the demand for kids’ smartwatches.In Europe, the technology has mostly been adopted in the UK, and other countries such as Italy and Spain are relatively slow in adopting it.
Global flame retardant apparel sales reached nearly 192 million square meter in 2018, with momentum likely to drive the market to a 6.2% y-o-y in 2019, according to Fact.MR’s latest analysis.
Imposition of stringent regulatory rules and growing awareness about workers’ safety in high-risk industries worldwide continue to drive growth.
Gains have also been driven by macroeconomic factors, notably stability in global oil prices and capital injection in infrastructure projects.
The report opines that effective implementation of workplace safety guidelines in developing countries can open up new opportunities for manufacturers.
The study predicts that the flame retardant apparel market will grow at an impressive 6.5% volume CAGR through 2027.The Fact.MR study thoroughly analyzes parameters of flame retardant apparel market growth to provide comprehensive and insightful information about the future prospects of the global flame retardant apparel market.Oil & Gas and Power Generation Industries Create Promising Growth OpportunitiesThe Fact.MR study on flame retardant apparel market offers demand and supply analysis for flame retardant apparels across various end-user industries, such as mining, petrochemical, oil & gas, power, and automotive & transportation.
According to the study, the oil & gas industry remains the largest consumer of flame retardant apparels.The oil & gas industry is one of the high-risk industries that can pose serious harm to workers’ health and is prone to severe workplace accidents.
Rainscreen Cladding Market – OverviewThe increased investment is anticipated to fuel the demand for rainscreen cladding market.
Reports that judge the construction industry has been offered by Market Research Future, which generates reports on industry verticals that judge the market development and possibilities.
The inclination towards eco-friendly buildings construction is anticipated to bolster the market for rainscreen cladding globally.Segmental AnalysisThe segmental outline of the rainscreen cladding market is carried out on the basis of type, end-use, and region.
The end-use basis of segmenting the rainscreen cladding market consists of commercial, residential, and industrial.
The market is further determined with the opening of rules and regulations by the European Commission with the aim of motivating the use of energy in a resourceful way across all end-use industries such as housing, business, and industrial properties.Competitive AnalysisThe strategic intent in the market of players is enhancing the operations in the market overall.
The extensive set of capabilities developed by market players is aiding in accelerating and delivering sustainable growth.
