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Mineralocorticoid receptor drugs development analysis

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t T2D.36ohnson & Johnson maintained its top position, with its market cap for Q1 2022 growing by 3.5% from $450.4 billion to $466.0 billion as of March 31, 2022. The limited success of Johnson & Johnson’s COVID-19 vaccine following concerns of a possible link to thromboembolic events has led the company to further diversify its pipeline with oncology Mineralocorticoid receptor drugs therapies for multiple myeloma and leukemia. Carvykti (ciltacabtagene autoleucel), the company’s cell therapy for adults with relapsed or refractory multiple myeloma, received regulatory approval from the FDA in Q1 2022 following positive pivotal Phase II trial data. Carvykti is set to become a blockbuster drug with the analyst consensus global sales forecast of $4.2 billion by 2028, according to GlobalData’s Drugs Database Pharma Intelligence Center.

Moderna, which previously reaped success from its COVID-19 mRNA-1273 vaccine, dropped four places after experiencing the largest decrease of -32.6% in market cap over Q1 2022, with its share price plummeting from $103 on December 31, 2021 to $69.4 on March 31, 2022.

BioNTech, which saw significant market cap growth in Q4 2021 after dominating the COVID-19 market alongside Pfizer and Moderna, did not make the list after experiencing a 32.6% market cap setback in Q1 2022. A potential decrease in market cap for some COVID-19 drug biopharmaceutical companies may persist due to current uncertainty in financial markets with a waning vaccine demand as the pandemic continues to ease.

AstraZeneca showed a strong stock market performance in Q1 2022, with its market cap for Q1 2022 growing by 19.0% from $173.2 billion to $206.1 billion as of March 31, 2022. This growth was largely due to the sales of Tagrisso (osimertinib), its treatment for patients with non-small cell lung cancer, and a 40.6% growth in revenue. Tagrisso was AstraZeneca’s top-selling product in 2021 with analyst consensus global sales of $5.0 billion in 2021, according to GlobalData’s Drugs Database Pharma Intelligence Center, making up for the potential decline in sales of COVID-19 products amid diminishing demand and growing competition.

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