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Solid preparations for oral administration for children have the advantages of convenient carrying and good stability, but for children, they are prone to dysphagia.
Solubilization technologyAt present, most of the methods for improving the solubility of drugs on the market are mainly drug solubilization methods, including ①pH adjustment method: suitable for some weakly acidic and weakly basic drugs, by adjusting the pH value to increase the solubility of the drug; ②mixed solvent method: add a certain proportion of organic solvents (ethanol, glycerol, ethylene glycol, polyethylene glycol, etc.)
Nanocrystals technologyDue to the toxicity of solvents and surfactants, traditional drug solubilization methods are limited, so some drugs cannot achieve sufficient dosage concentrations.
In recent years, drug nanocrystals are a new type of nano drug delivery system.
Because nano-level drug crystals have a large specific surface area, according to the Ostwald-Freundlich and Noyes-Whitney formulas, this technology can effectively increase the saturated solubility of the drug, greatly improve the bioavailability, and reduce the dosage of the drug to a certain extent, thereby reducing the occurrence of adverse reactions.
In December 2015, a dry suspension of aprepitant was developed by a pharmaceutical company for pediatric patients from 6 months to 12 years old and was approved by the FDA for marketing.
